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Fig. 5 | Military Medical Research

Fig. 5

From: Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias

Fig. 5

Effects of PIASy silencing on Nav1.5 phosphorylation in the I/R rat model. Rat cardiomyocyte lysates were immunoprecipitated with an anti-Nav1.5 antibody, followed by immunoblotting with anti-phospho-tyrosine and anti-phospho-threonine antibodies. I/R ischemia/reperfusion, Nav1.5 voltage-gated sodium channel 1.5, PIASy protein inhibitor of activated STAT Y, shRNA short hairpin RNA

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Military Medical Research

ISSN: 2054-9369