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Table 2 Univariate and multivariate analyses of prognostic factors for ESCC patients’ survival

From: Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability

Variables

Univariate analysis

Multivariate analysis

HR

95% CI

P-value

HR

95% CI

P-value

Age (≥ 60 years/ < 60 years)

1.264

0.816–1.959

0.294

   

Gender (Male/female)

1.068

0.641–1.781

0.800

   

Differentiation (Poor/well and moderate)

1.061

0.580–1.943

0.847

   

Lymphatic metastasis (N1 – N3/N0)

1.855

1.265–2.808

0.002

1.386

0.902–2.132

0.137

pTNM stage (III/I – II)

1.812

1.213–2.707

0.004

1.541

1.126–2.110

0.007

HDAC7 expression (High/low)

2.200

1.471–3.290

< 0.001

1.999

1.321–3.027

0.001

USP10 expression (High/low)

2.799

1.843–4.250

< 0.001

1.725

1.032–2.885

0.038

c-Myc expression (High/low)

1.255

1.147–1.373

< 0.001

2.233

1.376–3.625

0.001

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Military Medical Research

ISSN: 2054-9369