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Fig. 1 | Military Medical Research

Fig. 1

From: An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screening

Fig. 1

Design and working principle of the microfluidic device. a Photograph of a fabricated device filled with red and green dyes. Scale bar = 1 cm. b Micrographs showing the process of single cell trapping, docking, cloning and drug stimulation followed live/dead cell staining. Scale bar = 50 μm. c Simulation of the flow velocity distribution around the microchamber without or with a cell trapped. The red arrows indicate the differences of the flow rates. d Show case of captured single K562 cell array stained with calcein-AM. Scale bar = 50 μm. e Work flow of single cells or single-cell derived clones-based drug effect evaluation on the microfluidic device

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