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Fig. 4 | Military Medical Research

Fig. 4

From: Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

Fig. 4

Docking simulation of CQ binding to PfLDH, PfOAT, PfPyrK, PfPGK and PfTPI proteins, respectively. The calculated binding affinities (kcal/mol) are -6.2, -6.1, -6.5, -5.7 and -5.8 for PfLDH, PfOAT, PfPyrK, PfPGK and PfTPI, respectively. Pf Plasmodium falciparum, LDH L-lactate dehydrogenase, OAT ornithine aminotransferase, PyrK pyruvate kinase, PGK phosphoglycerate kinase, TPI triosephosphate isomerase

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