Table 1 Resveratrol, Quercetin, Curcumin, EGCG and Spermidine alleviates cardiac aging in animal models

Resveratrol

2 months old mice, 4.9 mg/(kg·d)

8 months

[24]

10 months old mice, 20 mg/(kg·d)

4 d

[25]

14 months old mice, 50 mg/(kg·d)

16 months

[26]

Quercetin

1 year old diabetic Zucker Diabetic Fatty rats, 20 mg/(kg·d)

6 weeks

[27]

8 weeks old dystrophin-deficient mice, diet with 0.2% quercetin

8 months

[28]

Curcumin

26–28 months old rats, 50 mg/(kg·d)

2 months

[29]

EGCG

16 months old mice, 50 mg/(kg·d)

8 weeks

[30]

24–26 months old mice, 200 mg/(kg·d)

1 month

[31]

Spermidine

4 months old mice, 3 mmol/L in drinking water

26 months

[32]

18 months old mice, 3 mmol/L in drinking water

6 months

[33]

27–29 months old mice, 3 mmol/L in drinking water

4 weeks

[34]

7 weeks old Dahl salt-sensitive rats, 3 mmol/L in drinking water

12 weeks

[32]

22–24 months old rats, 10 mg/(kg·d)

6 weeks

[35]