Fig. 2

Gradual recovery of the oral microbiome. a Neutralizing antibodies and IgG gradually decreased from CPR0 to CPR1 to HC. b As estimated by the Shannon index, the oral microbial α diversity gradually increased. c The PCoA showed that the compositions and β diversity gradually recovered. d Key oral bacteria whose abundance gradually increased or decreased were identified at the phylum and genus levels among three groups. e Heatmap displays the gradual recovery of the key OTUs in the oral microbiome. ^**P < 0.01, ^***P < 0.001, compared among three groups. CPR0 confirmed patients recover at discharge, CPR1 confirmed patients recover 1 year, HC healthy control, PCoA principal coordinate analysis, OTUs operational taxonomy units