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Fig. 7 | Military Medical Research

Fig. 7

From: Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

Fig. 7

Schematic representation of activation-induced pyroptosis of mucosal-associated invariant T (MAIT) cells in chronic human immunodeficiency virus type 1 (HIV-1) infection. Following chronic HIV-1 infection, MAIT cells decreased in peripheral blood and homed to the gut mucosa due to activation-induced pyroptosis in response to multiple stimuli, including HIV-1 virions, IL-12, and IL-18 stimulation. This correlates with HIV-1 disease progression and severity of microbial translocation. However, MAIT-cell pyroptosis decreased in CRs but remained higher in INRs following successful combined antiretroviral therapy. TP treatment-naive patient, CR complete responder, INR immunological non-responder, IL-12 interleukin-12, IL-18 interleukin-18, sCD14 soluble CD14, I-FABP intestinal fatty acid-binding protein, DC dendritic cells

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