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Fig. 6 | Military Medical Research

Fig. 6

From: Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis

Fig. 6

Scheme of activated Drp1 regulating p62-mediated autophagic flux and aggravating inflammation in CIRI. Drp1 activation following CIRI accelerates the p62-mediated formation of autophagosomes while inhibiting the autophagosome to autolysosome transition by activating the RIP1/RIP3 pathway. Undegraded autophagosomes are secreted extracellularly in the form of exosomes, causing an inflammatory response that further damages mitochondria, results in massive ROS generation, and blockage of autophagosomal degradation. CIRI cerebral ischemia–reperfusion injury, ROS reactive oxygen species

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Military Medical Research

ISSN: 2054-9369