Fig. 4

CENPK enhances tumorigenic functions of cervical cancer cells in vivo. a qPCR analyses of CENPK mRNA levels in HeLa and SiHa-derived xenografts with CENPK silencing and controls. b-d Impact of CENPK on cervical cancer proliferation (n = 5/group), metastasis (n = 5/group), and tumor formation ability (n = 6/group) was detected by establishing the xenograft mouse models. Tumor volume (e) and tumor weight (f) were calculated and recorded. g Xenograft tumors were subjected to detection of Ki67 expression by immunohistochemistry (IHC). h Survival analyses were performed to compare the overall survival time of the mice in the CENPK-silenced group (n = 10), the cisplatin/carboplatin-treated group (n = 10), the CENPK knockdown plus cisplatin/carboplatin-treated group (n = 10), and the controls (n = 10). Data are represented as the mean ± SD. ^**P < 0.01, ^***P < 0.001