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Table 2 Analysis of the 5-year overall survival rates of patients using the 8th AJCC pN classification stratified into limited (< 16 rLNs) and adequate (≥ 16 rLNs) rLN set (SEER multiethnicity dataset)

From: Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data

Stage

Limited rLN dataset

Stage

Adequate rLN dataset

P value (Limited vs. Adequate rLN dataset)

Stage

Combined rLN dataset

n (%)

5-year OS (%)

n (%)

5-year OS (%)

n (%)

5-year OS (%)

pN (n = 5429)

 

pN (n = 4779)

  

pN (n = 10,208)

 

 N0

2516 (46.3)

57.3

 

1499 (31.4)

71.5

 < 0.001

 

4015 (39.3)

62.2

 N1

1258 (23.2)

32.1

 

810 (16.9)

54.7

 < 0.001

 

2068 (20.3)

40.3

 N2

1037 (19.1)

24.3

 

813 (17.0)

37.3

 < 0.001

 

1850 (18.1)

29.9

 N3a

618 (11.4)

10.8

 

1036 (21.7)

22.0

 < 0.001

 

1654 (16.2)

17.8

 N3b

–

–

 

621 (13.0)

9.0

–

 

621 (6.1)

9.0

*pN’ (n = 4325)

 

*pN’ (n = 5883)

  

pN’ (n = 10,208)

 

 N’0

–

–

 

2603 (44.2)*

71.8

–

 

2603 (25.5)

71.8

 N’1

1412 (32.6)

46.4

 

810 (13.8)

54.7

0.011

 

2222 (21.8)

49.1

 N’2

1258 (29.1)

32.1

 

813 (13.8)

37.3

0.001

 

2071 (20.3)

34.1

 N’3a

1037 (24.0)

24.3

 

1036 (17.6)

22.0

0.854

 

2073 (20.3)

23.2

 N’3b

618 (14.3)

10.8

 

621 (10.6)

9.0

0.548

 

1239 (12.1)

9.9

pTNM (n = 5429)

 

pTNM (n = 4779)

  

pTNM (n = 10,208)

 

 IA

1104 (20.3)

  

614 (12.8)

85.2

 < 0.001

 

1718 (16.8)

76.6

 IB

652 (12.0)

56.4

 

396 (8.3)

74.2

 < 0.001

 

1048 (10.3)

62.6

 IIA

876 (16.1)

44.1

 

631 (13.2)

62.7

 < 0.001

 

1507 (14.8)

51.3

 IIB

878 (16.2)

32.9

 

629 (13.2)

46.9

 < 0.001

 

1507 (14.8)

38.2

 IIIA

1164 (21.4)

22.0

 

848 (17.7)

38.9

 < 0.001

 

2012 (19.7)

28.9

 IIIB

672 (12.4)

12.4

 

971 (20.3)

22.1

 < 0.001

 

1643 (16.1)

18.1

 IIIC

83 (1.5)

1.9

 

690 (14.4)

8.7

0.093

 

773 (7.6)

7.8

*pTN’M (n = 4325)

 

*pTN’M (n = 5883)

  

pTN’M (n = 10,208)

 

 IA’

   

1718 (29.2)*

76.6

  

1718 (16.8)

76.6

 IB’

   

396 (6.7)

74.2

  

396 (3.9)

74.2

 IIA’

652 (15.1)

56.4

 

631 (10.7)

62.7

0.066

 

1283 (12.6)

59.3

 IIB’

876 (20.3)

44.1

 

629 (10.7)

46.9

0.356

 

1505 (14.7)

45.1

 IIIA’

1116 (25.8)

30.4

 

848 (14.4)

38.9

 < 0.001

 

1964 (19.2)

33.9

 IIIB’

1009 (23.3)

21.5

 

971 (16.5)

22.1

0.071

 

1980 (19.4)

21.8

 IIIC’

672 (15.5)

10.7

 

690 (11.7)

8.7

0.704

 

1362 (13.3)

9.7

  1. *Contained patients with pT1N0M0 lesions (SEER dataset, n = 1104) from the Limited set who were not reclassified to 1 higher nodal stage to minimize data heterogeneity, as less extensive surgeries (i.e., D1 or D1 + gastrectomy) were performed in these patients, compared to the rest of the dataset, and additionally there was no significant difference in OS between the pT1N0M0 of the Limited and Adequate set (P = 0.466; data not shown).—no cases, rLNs retrieved lymph nodes, OS overall survival rate, AJCC American Joint Committee on Cancer, pN pathological nodal classification, pN’ modified pathological nodal classification, pTNM pathological tumor-node-metastasis classification, pTN’M pathological tumor-modified node-metastasis classification
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