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Table 1 Analysis of the 5-year overall survival rates of patients using the 8th AJCC pN classification stratified into limited (< 16 rLNs) and adequate (≥ 16 rLNs) rLN set (Chinese multicenter dataset)

From: Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data

Stage

Limited rLN dataset

Stage

Adequate rLN dataset

P value (Limited vs. Adequate rLN dataset)

Stage

Combined rLN dataset

n (%)

5-year OS (%)

n (%)

5-year OS (%)

n (%)

5-year OS (%)

pN (n = 2414)

 

pN (n = 5497)

  

pN (n = 7911)

 

 N0

1063 (44.0)

72.2

 

1807 (32.9)

84.0

 < 0.001

 

2870 (36.3)

79.6

 N1

518 (21.5)

45.5

 

885 (16.1)

65.5

 < 0.001

 

1403 (17.7)

57.6

 N2

558 (23.1)

32.0

 

989 (18.0)

51.2

 < 0.001

 

1547 (19.6)

44.0

 N3a

275 (11.4)

13.2

 

1132 (20.6)

30.3

 < 0.001

 

1407 (17.8)

26.9

 N3b

–

–

 

684 (12.4)

14.9

–

 

684 (8.6)

14.9

*pN’ (n = 2164)

 

*pN’ (n = 5747)

  

pN’ (n = 7911)

 

 N’0

–

–

 

2057 (35.8)*

85.5

–

 

2057 (26.0)

85.5

 N’1

813 (37.6)

65.3

 

885 (15.4)

65.5

0.913

 

1698 (21.5)

65.3

 N’2

518 (23.9)

45.5

 

989 (17.2)

51.2

0.018

 

1507 (19.0)

49.1

 N’3a

558 (25.8)

32.0

 

1132 (19.7)

30.3

0.437

 

1690 (21.4)

30.9

 N’3b

275 (12.7)

13.2

 

684 (11.9)

14.9

0.582

 

959 (12.1)

14.4

pTNM (n = 2414)

 

pTNM (n = 5497)

  

pTNM (n = 7911)

 

 IA

250 (10.4)

95.9

 

551 (10.0)

96.9

0.466

 

801 (10.1)

96.6

 IB

227 (9.4)

77.3

 

508 (9.2)

87.8

 < 0.001

 

735 (9.3)

84.4

 IIA

234 (9.7)

66.4

 

465 (8.5)

80.2

 < 0.001

 

699 (8.8)

75.5

 IIB

587 (24.3)

57.3

 

912 (16.6)

66.8

 < 0.001

 

1499 (18.9)

63.0

 IIIA

785 (32.5)

34.2

 

1291 (23.5)

51.1

 < 0.001

 

2076 (26.2)

44.5

 IIIB

294 (12.2)

14.4

 

1046 (19.0)

30.0

 < 0.001

 

1340 (16.9)

26.4

 IIIC

37 (1.5)

5.0

 

724 (13.2)

14.0

0.066

 

761 (9.6)

13.6

*pTN’M (n = 2164)

 

*pTN’M (n = 5747)

  

pTN’M (n = 7911)

 

 IA’

–

–

 

801 (13.9)*

96.6

–

 

801 (10.1)

96.6

 IB’

–

–

 

508 (8.8)

87.8

–

 

508 (6.4)

87.8

 IIA’

227 (10.5)

77.3

 

465 (8.1)

80.2

0.657

 

692 (8.7)

79.2

 IIB’

234 (10.8)

66.4

 

912 (15.9)

66.8

0.826

 

1146 (14.5)

66.7

 IIIA’

890 (41.1)

51.0

 

1291 (22.5)

51.1

0.753

 

2181 (27.6)

51.1

 IIIB’

515 (23.8)

30.7

 

1046 (18.2)

30.0

0.949

 

1561 (19.7)

30.2

 IIIC’

298 (13.8)

11.7

 

724 (12.6)

14.0

0.706

 

1022 (12.9)

13.3

  1. *Contained patients with pT1N0M0 lesions (Chinese dataset, n = 250) from the Limited set who were not reclassified to 1 higher nodal stage to minimize data heterogeneity, as less extensive surgeries (i.e., D1 or D1 + gastrectomy) were performed in these patients, compared to the rest of the dataset, and additionally there was no significant difference in OS between the pT1N0M0 of the Limited and Adequate set (P = 0.466; data not shown).—no cases, rLNs retrieved lymph nodes, OS overall survival rate, AJCC American Joint Committee on Cancer, pN pathological nodal classification, pN’ modified pathological nodal classification, pTNM pathological tumor-node-metastasis classification, pTN’M pathological tumor-modified node-metastasis classification