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Fig. 2 | Military Medical Research

Fig. 2

From: Advances in electrical impedance tomography-based brain imaging

Fig. 2

Progress in EIT for epilepsy. a Impedance response in the cortex and thalamus was characterized during forepaw stimulation using a 57-channel electrode array placed on the cortex and a depth electrode placed in the VPL nucleus in the thalamus. EIT imaging was conducted in an attempt to image ascending neural activity from the thalamus to the cortex using epicortical electrodes. b Protocol that maximizes current density in the VPL was used for imaging experiments. c Average current density across injection pairs concentrated in a sagittal slice when using the protocol that maximizes current density in the VPL. The location of the VPL is highlighted in white. d Data collection and processing work flow. e Angular bundle of the perforant path was electrically stimulated with a 2-s train of 100 Hz biphasic square-wave pulses to induce seizures. Pulses were 1 ms in duration per phase and 1.5 mA in amplitude. f During each imaging protocol, transfer impedances were recorded by injecting current through a different electrode pair on the 54-electrode epicortical array for each of ≥ 30 seizures; locations of and the distance between current-injecting electrodes were varied to ensure adequate sampling of the cortex and hippocampus. A 12-min rest period between stimulation series ensured that seizures remained stable during imaging protocols. Adapted from [56, 57]. EIT electrical impedance tomography, VPL ventral posterolateral

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