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Fig. 6 | Military Medical Research

Fig. 6

From: FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells

Fig. 6

FGF2 was upregulated through HDM treatment and amplified the release levels of IL-6 and IL-8 induced by IL-1β in A549 cells via FGFR/MAPK/NF-κB signalling. a Western blotting analysis showing the upregulation of FGF2 protein abundance induced by HDM treatment in A549 cells at different time points. b IL-6 and IL-8 release levels were measured through ELISA 48 h post treatments (n = 3). Data are represented as mean ± standard error of the mean. c RT-qPCR results showing the IL-6 and IL-8 mRNA levels among treatment groups. mRNA levels were normalised to the housekeeping gene, GAPDH. d Representative Western blotting showing the protein levels of p-ERK1/2, total-ERK1/2, p-p38, total-p38, p-p65, and p-IκB in A549 cells 15 min post treatments. *P < 0.05, **P < 0.01, and ***P < 0.001. PD FGFR inhibitor PD173074, rh-FGF2 recombinant human FGF2, Sham negative control

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