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Fig. 6 | Military Medical Research

Fig. 6

From: Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer

Fig. 6

Effects of LR004-VC-MMAE on cell apoptosis and cell cycle phase distribution in TNBC cells. a Apoptosis analysis of MDA-MB-468 and MDA-MB-231 cells. Cell apoptosis was assessed by FACS after treatment with 10 or 50 μmol/L LR004-VC-MMAE for 48 h. b Cell cycle phase analysis in MDA-MB-468 and MDA-MB-231 cells. Cells were treated with 10 or 50 μmol/L LR004-VC-MMAE for 48 h, stained with propidium iodide (PI), and the cell cycle phase distribution was analyzed by FACS. c Quantitative analysis of the cell cycle phase distribution in MDA-MB-468 and MDA-MB-231 cells. The experiments were performed in triplicate. Data are presented as mean ± SD. **P < 0.01, ***P < 0.001 vs. control

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Military Medical Research

ISSN: 2054-9369