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Fig. 4 | Military Medical Research

Fig. 4

From: Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer

Fig. 4

Inhibitory effects of LR004-VC-MMAE on CSCs in TNBC cells. a Proportions of CD133+ CSCs subpopulation in MDA-MB-468 and MDA-MB-231 cells. The cells were analyzed by FACS after treatment with 5 nmol/L LR004-VC-MMAE for 48 h. b Proportions of CD44+/CD24−/low CSCs subpopulation in MDA-MB-468 and MDA-MB-231 cells. The cells were analyzed by FACS after treatment with 5 nmol/L LR004-VC-MMAE for 48 h. c Tumorspheres formed by MDA-MB-468 and MDA-MB-231 cells. The cells were treated with the indicated concentrations of LR004-VC-MMAE. Representative images of tumorspheres and the enumeration of tumorspheres are shown. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control. SSC side scatter, CSC cancer stem cell, TNBC triple-negative breast cancer

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Military Medical Research

ISSN: 2054-9369