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Fig. 5 | Military Medical Research

Fig. 5

From: Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Fig. 5

Silencing LMP2 rescued the downregulation of the Wnt-3a and β-catenin proteins in RBMVECs following OGD/R. a Immunofluorescence and quantitative analysis of β-catenin protein in RBMVECs under normal condition culture and OGD/R conditions. Scale bars = 50 µm. b and c Western blotting indicated that the expression of β-catenin and Wnt-3a proteins in RBMVECs in each group. Data are presented as the mean ± standard deviation (SD) from three independent experiments. *P < 0.001, compared with the normal group; #P < 0.001, compared with the control-siRNA group. OGD/R oxygen–glucose deprivation and reoxygenation; RBMVECs rat brain microvascular endothelial cells

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Military Medical Research

ISSN: 2054-9369