Skip to main content
Fig. 4 | Military Medical Research

Fig. 4

From: Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Fig. 4

Silencing LMP2 reversed the downregulated expression of the occludin, claudin-1 and ZO-1 proteins in RBMVECs following OGD/R. a Transfection efficiency of LMP2-siRNA was verified by RT-PCR and Western blotting. *P < 0.001, compared with the Si1 group, #P < 0.001, compared with the Si2 group. &P < 0.001, compared with the NC group. b Western blotting showed that the levels of occludin, claudin-1 and ZO-1 proteins in RBMVECs in each group. Data are presented as the mean ± standard deviation (SD) from three independent experiments. *P < 0.001, compared with the normal group; #P < 0.001, compared with the control-siRNA group. OGD/R oxygen–glucose deprivation and reoxygenation; NC group negative control group; RBMVECs rat brain microvascular endothelial cells

Back to article page

Military Medical Research

ISSN: 2054-9369