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Fig. 1 | Military Medical Research

Fig. 1

From: Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Fig. 1

LMP2 inhibition increased the levels of tight junction proteins, improved BBB integrity and upregulated Wnt/β-catenin signalling after MCAO. a Western blotting showed the levels of tight junction proteins occludin, claudin-1, ZO-1 proteins in each group rats. b Immunofluorescence staining and quantitative analysis of CD31 in brain cortex tissue from each group rats. c FITC-dextran angiographic micrographs and quantitative analysis of FITC in brain cortex tissue from each group rats. d Representative Western blotting images of Wnt-3a and β-catenin proteins in brain cortex tissue from each group rats. Data are presented as the mean ± standard deviation (SD) from three independent experiments (each group rats n = 4). *P < 0.001, compared with the sham group; #P < 0.001, compared with the control-shRNA group. All scale bars = 50 µm

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Military Medical Research

ISSN: 2054-9369