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Fig. 4 | Military Medical Research

Fig. 4

From: Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model

Fig. 4

Melatonin activates ERK/NRF2/HO-1 signaling pathway in postradiation CBSCs. a Levels of TNF-α and IL-6 in CBSCs were detected by Western blotting. b, c Intracellular markers of ERK/NRF2/HO-1 signaling were measured by Western blotting. *P < 0.05 compared with control; #P < 0.05 compared with IR. d Levels of HO-1, TNF-α and IL-6 were detected after postradiation CBSCs were treated with melatonin and inhibitors. e Levels of oxidative stress-related markers were measured after postradiation CBSCs were treated with melatonin and inhibitors. Compared with IR, *P < 0.05; compared with IR + MLT, #P < 0.05. IR irradiation, MLT melatonin, CBSCs cortical bone-derived stem cells, ERK extracellular regulated kinase, NRF2 nuclear factor erythroid 2-related factor 2, HO-1 heme oxygenase-1, TNF-α tumor necrosis factor alpha, IL-6 interleukin-6

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