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Fig. 2 | Military Medical Research

Fig. 2

From: Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model

Fig. 2

Effect of melatonin on DNA damage and apoptosis of postradiation CBSCs. a Analysis of DNA breaks using γH2AX immunostaining. DAPI (blue) and γH2AX (red). b Analysis of apoptosis by flow cytometry. c Levels of anti-apoptotic protein BCL-2 and pro-apoptotic protein BAX were measured by Western blotting. Compared with control, *P < 0.05; compared with IR, #P < 0.05. IR irradiation, IR + LMLT irradiation plus low 1 μmol/L melatonin treatment, IR + MMLT irradiation plus medium 10 μmol/L melatonin treatment, IR + HMLT irradiation plus high 100 μmol/L melatonin treatment, CBSCs cortical bone-derived stem cells, γH2AX gamma H2A histone family member X, BCL-2 B-cell lymphoma-2, BAX BCL2-associated X

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