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Table 4 Distribution of mtDNA variants defining mtDNA haplogroups among controls and severe cases

From: Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

MtDNA variations

MtDNA haplogroups

Controls (n = 615) [n(%)]

Severe cases (n = 451) [n(%)]

P value (χ2)a

Adjusted P valueb

OR (95% CI) b

A663G

A

39 (6.34)

38 (8.43)

0.231

0.141

1.451 (0.884–2.381)

8281–8289d c

B

118 (19.19)

78 (17.29)

0.472

0.202

0.796 (0.561–1.130)

C5178a c

D

176 (28.62)

85 (18.85)

 < 0.001

0.001

0.590 (0.428–0.814)

A249d/T6392C/G10310A

F

129 (20.98)

66 (14.63)

0.008

0.020

0.654 (0.457–0.936)

A4833G

G

16 (2.60)

29 (6.43)

0.003

0.015

2.336 (1.179–4.608)

T9824C

M7

33 (5.37)

36 (7.98)

0.101

0.390

0.795 (0.472–1.341)

A4715G

M8 (M8a + C + Z)

36 (5.85)

53 (11.75)

0.001

0.005

2.033 (1.242–3.322)

T3394C

M9

18 (2.93)

28 (6.21)

0.010

0.002

3.040 (1.522–6.061)

T489C/C10400T/T14783C/G15043A

M* (M2 + M10 + M11 + 

M13a + M)

32 (5.20)

17 (3.77)

NA

  

G5417A/C16257a/C16261T

N9a

11 (1.79)

19 (4.21)

0.023

0.018

2.890 (1.199–6.993)

T1391C/T16311C

R1

7 (1.14)

2 (0.44)

0.316

0.358

0.460 (0.088–2.410)

  1. aχ2-test or Fisher's exact test. Bonferroni corrected P < 0.05/n (n = 15)
  2. bAdjusted P value and ORs (95% CIs) determined by multivariate logistic regression analysis, adjusted for age, gender, smoking and diseases (including cardiopulmonary diseases, diabetes, obesity and hypertension determined through clinical and radiographic examinations)
  3. cThe letter “d” indicates nucleotide deletion, the letter “a” indicates nucleotide transversion
  4. NA not available