Table 2 Frequencies of mtDNA variants defining mtDNA haplogroups among controls and pooled cases
MtDNA variations | mtDNA haplogroups | Controls (n = 615) [n(%)] | Pooled cases (n = 536) [n(%)] | P value (χ2)a | Adjusted P valueb | OR (95% CI)b |
|---|---|---|---|---|---|---|
A663G | A | 39 (6.34) | 48 (8.96) | 0.117 | 0.060 | 1.567 (0.980–2.500) |
8281-8289d c | B | 118 (19.19) | 87 (16.23) | 0.217 | 0.150 | 0.781 (0.557–1.093) |
C5178a c | D | 176 (28.62) | 110 (20.52) | 0.002 | 0.012 | 0.681 (0.504–0.919) |
A249d/T6392C/G10310A | F (F1 + F3) | 129 (20.98) | 77 (14.37) | 0.004 | 0.002 | 0.639 (0.483–0.847) |
A4833G | G | 16 (2.60) | 32 (5.97) | 0.005 | < 0.001 | 4.384 (2.103–9.137) |
T9824C | M7 | 33 (5.37) | 41 (7.65) | 0.119 | 0.519 | 1.181 (0.712–1.957) |
A4715G | M8 (M8a + C + Z) | 36 (5.85) | 59 (11.01) | 0.002 | 0.009 | 1.876 (1.167–3.021) |
T3394C | M9 | 18 (2.93) | 30 (5.60) | 0.027 | 0.005 | 2.618 (1.339–5.128) |
G16274A | M2 | 8 (1.30) | 5 (0.93) | 0.399 | 0.896 | 0.899 (0.180–4.484) |
T16126C | M3 | 10 (1.63) | 7 (1.30) | 0.616 | 0.466 | 0.572 (0.128–2.567) |
T16311C | M10 | 9 (1.46) | 6 (1.12) | 0.592 | 0.418 | 0.509 (0.099–2.610) |
G6023A | M13 | 4 (0.65) | 4 (0.75) | 1.000 | 0.514 | 0.566 (0.102–3.137) |
T489C/C10400T/T14783C/G15043A | M* | 1 (0.16) | 1 (0.19) | 1.000 | NA | |
G5417A/C16257a/C16261T | N9a | 11 (1.79) | 27 (5.04) | 0.003 | 0.004 | 3.401 (1.486–7.752) |
T1391C/T16311C | R1 | 7 (1.14) | 2 (0.37) | 0.187 | 0.219 | 0.353 (0.067–1.859) |