Fig. 5From: RIG-I, a novel DAMPs sensor for myoglobin, activates NF-κB/caspase-3 signaling in CS-AKI modelSchematic drawing of the novel RIG-I signaling pathway in CS-AKI. In the crush syndrome related acute kidney injury (CS-AKI) rat model, muscle tissue releases large amounts of myoglobin to injure the kidney. Myoglobin binds to RIG-I after endocytosis, then mainly activate NK-κB/caspase-3 axis, not the classical IRF-3/IFN-β signaling pathway in CS-AKI rat kidney. In this process, the expression of pro-inflammation cytokines IL-6 and TNF-α are also increased to some degreeBack to article page