Fig. 1
From: RIG-I, a novel DAMPs sensor for myoglobin, activates NF-κB/caspase-3 signaling in CS-AKI model
The expression of RIG-I in the CS-AKI rat model. DEGs: Differentially expressed genes. a–d. Serum levels of CK, Scr, BUN, and Mb. e–f. qPCR analysis of renal KIM-1 and NGAL expression. g. HE and PAS staining of kidney tissues (scale bar: 100 μm). h. Renal tubular injury score, as determined by calculating the percentage of tubules that displayed tubular dilation, cast formation and tubular necrosis: 0, normal; 1, ≤10%; 2, 10–25%; 3, 26–50%; 4, 51–75%; 5, ≥75%. i. DEGs between the sham and CS groups, as identified by RNA sequencing. j. The 10 signaling pathways, as identified by KEGG pathway analysis. k–o. qPCR, Western blotting and IHC analyses (scale bar: 100 μm) of renal RIG-I expression. Data are expressed as the mean ± SD (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA followed by the Bonferroni’s multiple comparisons test