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Table 2 Top 30 significantly down-regulated DE genes and GO annotations after NBXH treatment

From: Comparative study on the antituberculous effect and mechanism of the traditional Chinese medicines NiuBeiXiaoHe extract and JieHeWan

Gene symbol Fold change in DE Gene ontology annotations
NBXH group vs. TB model group TB model group vs. normal control group JHW vs. TB model group BP CC MF
Zc3h11a −5.22 2.08 NO poly(A) + mRNA export from nucleus NO NO
C5ar1 −2.98 1.07 NO Positive regulation of vascular endothelial growth factor production, negative regulation of neuron apoptotic process, positive regulation of macrophage chemotaxis, etc. Cell surface, apical part of cell, cytoplasmic vesicle NO
Mouse_newGene_1010 −2.88 NO NO NO NO NO
Matn4 −2.68 2.41 −3.11 Response to axon injury Extracellular region NO
Mouse_newGene_34078 −2.62 1.57 NO NO NO NO
Mouse_newGene_22362 −2.58 NO −9.68 Translation, ribosomal small subunit assembly, single organismal cell-cell adhesion, etc. Basement membrane, neuronal cell body, cytosolic small ribosomal subunit, etc. Structural constituent of ribosome, laminin binding, ribosome binding
Mouse_newGene_31321 −2.54 NO NO NO NO NO
Mouse_newGene_3400 −2.32 2.25 NO Mucosal immune response, humoral immune response mediated by circulating immunoglobulin Immunoglobulin complex, circulating Antigen binding
Rpl10-ps3 −2.24 2.31 NO rRNA processing, SRP-dependent cotranslational protein targeting to membrane, liver regeneration, etc. Cytosolic large ribosomal subunit, polysome Structural constituent of ribosome
Mouse_newGene_59 −2.23 1.35 −2.01 erythrocyte differentiation NO NO
Mouse_newGene_11641 −1.93 4.46 NO Response to oxidative stress, negative regulation of cell proliferation, negative regulation of mitotic cell cycle, etc. NO NO
Mouse_newGene_10816 −1.90 2.61 −1.54 Negative regulation of catalytic activity NO Enzyme binding
Mouse_newGene_11438 −1.88 4.921 2.69 Regulation of protein ubiquitination NO NO
Mouse_newGene_35672 −1.88 1.31 NO NO NO Ligase activity
Pcdhgc3 −1.86 2.17 NO Nervous system development, synapse organization, cell-cell signaling, etc. Cell-cell junction NO
Mouse_newGene_8457 −1.77 1.18 NO Lipoprotein metabolic process, lipid transport Extracellular region Lipid binding, signal transducer activity
Plcxd1 −1.70 NO NO Lipid metabolic process NO NO
Mouse_newGene_25732 −1.70 1.77 −0.74 NO NO antigen binding
Zc3h11 −1.69 0.94 −0.92 poly(A) + mRNA export from nucleus NO NO
Gm29094 −1.65 3.07 NO Intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, extrinsic apoptotic signaling pathway in absence of ligand, etc. Mitochondrial outer membrane Ligase activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Mouse_newGene_3696 −1.57 1.10 −1.31 Regulation of RNA splicing, mrna processing Catalytic step 2 spliceosome Single-stranded RNA binding, TBP-class protein binding, nucleotide binding
Mouse_newGene_21297 −1.56 3.74 −1.38 NO NO NO
Stac3 −1.45 NO NO Skeletal muscle contraction, skeletal muscle fiber development, neuromuscular synaptic transmission, etc. NO NO
Msi1 −1.42 NO NO Response to hormone, epithelial cell differentiation Polysome Nucleotide binding, poly(u) rna binding
Ccnb1ip1 −1.42 3.06 0.81 Protein ubiquitination, spermatid development Synaptonemal complex Ligase activity, ubiquitin protein ligase activity
Mouse_newGene_16290 −1.36 NO −2.61 Locomotory behavior, nervous system development, social behavior Dense core granule Aminoacyl-trna ligase activity
Mouse_newGene_15544 −1.36 1.33 NO NO NO NO
Mouse_newGene_27195 −1.36 1.85 NO Cellular response to estradiol stimulus, response to nutrient levels, glucocorticoid biosynthetic process Rough endoplasmic reticulum, apical part of cell, nuclear membrane 11-beta-hydroxysteroid dehydrogenase [nad(p)] activity, steroid binding, nadp binding
Mouse_newGene_5048 −1.31 2.30 −0.85 NO NO NO
Mouse_newGene_3462 −1.31 1.56 −1.36 NO NO NO
  1. The data are displayed as the logarithm of the fold change [log2(FC)]. Positive number, up-regulated; Negative number, down-regulated; NO. Not found in the database
  2. DE differentially expressed, GO gene ontology, BP biological process, CC cellular component, MF molecular function, NBXH NiuBeiXiaoHe, TB tuberculosis, JHW JieHeWan