Table 2 Top 30 significantly down-regulated DE genes and GO annotations after NBXH treatment
Gene symbol | Fold change in DE | Gene ontology annotations | ||||
|---|---|---|---|---|---|---|
NBXH group vs. TB model group | TB model group vs. normal control group | JHW vs. TB model group | BP | CC | MF | |
Zc3h11a | −5.22 | 2.08 | NO | poly(A) + mRNA export from nucleus | NO | NO |
C5ar1 | −2.98 | 1.07 | NO | Positive regulation of vascular endothelial growth factor production, negative regulation of neuron apoptotic process, positive regulation of macrophage chemotaxis, etc. | Cell surface, apical part of cell, cytoplasmic vesicle | NO |
Mouse_newGene_1010 | −2.88 | NO | NO | NO | NO | NO |
Matn4 | −2.68 | 2.41 | −3.11 | Response to axon injury | Extracellular region | NO |
Mouse_newGene_34078 | −2.62 | 1.57 | NO | NO | NO | NO |
Mouse_newGene_22362 | −2.58 | NO | −9.68 | Translation, ribosomal small subunit assembly, single organismal cell-cell adhesion, etc. | Basement membrane, neuronal cell body, cytosolic small ribosomal subunit, etc. | Structural constituent of ribosome, laminin binding, ribosome binding |
Mouse_newGene_31321 | −2.54 | NO | NO | NO | NO | NO |
Mouse_newGene_3400 | −2.32 | 2.25 | NO | Mucosal immune response, humoral immune response mediated by circulating immunoglobulin | Immunoglobulin complex, circulating | Antigen binding |
Rpl10-ps3 | −2.24 | 2.31 | NO | rRNA processing, SRP-dependent cotranslational protein targeting to membrane, liver regeneration, etc. | Cytosolic large ribosomal subunit, polysome | Structural constituent of ribosome |
Mouse_newGene_59 | −2.23 | 1.35 | −2.01 | erythrocyte differentiation | NO | NO |
Mouse_newGene_11641 | −1.93 | 4.46 | NO | Response to oxidative stress, negative regulation of cell proliferation, negative regulation of mitotic cell cycle, etc. | NO | NO |
Mouse_newGene_10816 | −1.90 | 2.61 | −1.54 | Negative regulation of catalytic activity | NO | Enzyme binding |
Mouse_newGene_11438 | −1.88 | 4.921 | 2.69 | Regulation of protein ubiquitination | NO | NO |
Mouse_newGene_35672 | −1.88 | 1.31 | NO | NO | NO | Ligase activity |
Pcdhgc3 | −1.86 | 2.17 | NO | Nervous system development, synapse organization, cell-cell signaling, etc. | Cell-cell junction | NO |
Mouse_newGene_8457 | −1.77 | 1.18 | NO | Lipoprotein metabolic process, lipid transport | Extracellular region | Lipid binding, signal transducer activity |
Plcxd1 | −1.70 | NO | NO | Lipid metabolic process | NO | NO |
Mouse_newGene_25732 | −1.70 | 1.77 | −0.74 | NO | NO | antigen binding |
Zc3h11 | −1.69 | 0.94 | −0.92 | poly(A) + mRNA export from nucleus | NO | NO |
Gm29094 | −1.65 | 3.07 | NO | Intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, extrinsic apoptotic signaling pathway in absence of ligand, etc. | Mitochondrial outer membrane | Ligase activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
Mouse_newGene_3696 | −1.57 | 1.10 | −1.31 | Regulation of RNA splicing, mrna processing | Catalytic step 2 spliceosome | Single-stranded RNA binding, TBP-class protein binding, nucleotide binding |
Mouse_newGene_21297 | −1.56 | 3.74 | −1.38 | NO | NO | NO |
Stac3 | −1.45 | NO | NO | Skeletal muscle contraction, skeletal muscle fiber development, neuromuscular synaptic transmission, etc. | NO | NO |
Msi1 | −1.42 | NO | NO | Response to hormone, epithelial cell differentiation | Polysome | Nucleotide binding, poly(u) rna binding |
Ccnb1ip1 | −1.42 | 3.06 | 0.81 | Protein ubiquitination, spermatid development | Synaptonemal complex | Ligase activity, ubiquitin protein ligase activity |
Mouse_newGene_16290 | −1.36 | NO | −2.61 | Locomotory behavior, nervous system development, social behavior | Dense core granule | Aminoacyl-trna ligase activity |
Mouse_newGene_15544 | −1.36 | 1.33 | NO | NO | NO | NO |
Mouse_newGene_27195 | −1.36 | 1.85 | NO | Cellular response to estradiol stimulus, response to nutrient levels, glucocorticoid biosynthetic process | Rough endoplasmic reticulum, apical part of cell, nuclear membrane | 11-beta-hydroxysteroid dehydrogenase [nad(p)] activity, steroid binding, nadp binding |
Mouse_newGene_5048 | −1.31 | 2.30 | −0.85 | NO | NO | NO |
Mouse_newGene_3462 | −1.31 | 1.56 | −1.36 | NO | NO | NO |