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Table 1 Top 30 significantly up-regulated DE genes and GO annotations after NBXH treatment

From: Comparative study on the antituberculous effect and mechanism of the traditional Chinese medicines NiuBeiXiaoHe extract and JieHeWan

Gene symbol Fold change in DE Gene ontology annotations
NBXH group vs. TB model group TB model group vs. normal control group JHW vs. TB model group BP CC MF
Rho 4.07 NO NO NO NO NO
Sap25 3.13 NO NO NO NO NO
Srp54a 2. 50 − 1.16 3.25 SRP-dependent cotranslational protein targeting to membrane; response to drug Nuclear speck GTP binding, GTPase activity, drug binding, etc.
Mouse_newGene_24952 2.06 −1.17 2.87 NO NO NO
Gm38394 1.89 −1.35 NO NO NO Transcription factor activity, sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, protein dimerization activity
Mouse_newGene_25840 1.76 −3.91 NO NO NO NO
Mouse_newGene_3409 1.64 −3.60 NO Humoral immune response mediated by circulating immunoglobulin, positive regulation of peptidyl-tyrosine phosphorylation, early endosome to late endosome transport, etc. Immunoglobulin complex, circulating, external side of plasma membrane, B cell receptor complex Antigen binding, transmembrane signaling receptor activity
Mouse_newGene_21033 1.51 −1.37 NO NO NO NO
Mouse_newGene_34719 1.37 NO NO NO NO GTPase activator activity
Mouse_newGene_1240 1.28 −1.17 1.16 Negative regulation of peptidase activity Extracellular region Ligase activity, serine-type endopeptidase inhibitor activity
Mouse_newGene_4366 1.26 NO 1.63 NO NO NO
Tmem229a 1.26 NO NO NO NO NO
Mouse_newGene_3520 1.24 −0.91 0.98 Response to hormone, positive regulation of stress-activated MAPK cascade, negative regulation of microtubule depolymerization, etc. Cytoplasmic microtubule Ligase activity, ubiquitin protein ligase binding
Rapgef5 1.23 −1.28 0.92 Small gtpase-mediated signal transduction, positive regulation of gtpase activity   GTP-dependent protein binding
Mapk14 1.22 NO 0.75 Lipopolysaccharide-mediated signaling pathway, response to muscle stretch, etc. Spindle pole Protein phosphatase binding, protein c-terminus binding
Slc5a1 1.17 NO NO NO NO NO
Kcna2 1.16 −2.43 NO NO NO NO
Mouse_newGene_31701 1.14 NO 0.98 Response to oxidative stress, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, etc. Lamellipodium, CD95 death-inducing signaling complex, growth cone, etc. Rac GTPase binding, GTPase activator activity, diacylglycerol choline phosphotransferase activity, etc.
Crispld2 1.13 NO NO Lung development, face morphogenesis, extracellular matrix organization Proteinaceous extracellular matrix, transport vesicle Heparin binding
Mouse_newGene_25226 1.13 −1.03 NO NO NO NO
Plekhs1 1.11 −0.86 NO NO NO NO
Pcdhgb7 1.11 NO NO Nervous system development, synapse organization, cell-cell signaling, etc. NO NO
Zfp273 1.10 −1.91 NO NO NO NO
Gpr27 1.09 NO 1.33 Positive regulation of insulin secretion involved in cellular response to glucose stimulus NO NO
Mouse_newGene_25949 1.09 −1.81 1.05 Response to lead ion Growth cone, filopodium Cholesterol binding
Mouse_newGene_12272 1.09 −1.33 NO NO NO NO
Jmjd8 1.09 −0.88 0.73 NO NO NO
Mouse_newGene_6388 1.08 −2.82 NO NO NO NO
Arhgap19 1.07 −1.30 NO Signal transduction NO GTPase activator activity
Zkscan7 1.06 −1.75 NO NO NO NO
  1. The data are displayed as the logarithm of the fold change [log2(FC)]. Positive number, up-regulated; Negative number, down-regulated; NO. Not found in the database
  2. DE differentially expressed, GO gene ontology, BP biological process, CC cellular component, MF molecular function, NBXH NiuBeiXiaoHe, TB tuberculosis, JHW JieHeWan