Fig. 5
From: Toll-like receptor 5-mediated signaling enhances liver regeneration in mice
Enhanced inflammatory response in CBLB502-pretreated mice after PHx. Serum TNF-α, IL-6, and G-CSF (a), and TGF-α and HGF (b) in CBLB502 treated mice at the indicated times. Serum TNF-α, IL-6, and G-CSF (c), and TGF-α and HGF (d) were measured in regenerating PBS and CBLB502 treated mouse livers after PHx. e Relative mRNA levels of hepatic c-Fos, c-Myc, c-Jun, TNF-α, and IL-6 in PBS and CBLB502 treated mice after PHx. f Cell counts of liver MNCs, neutrophils, KCs, and recruited macrophages in PBS and CBLB502 treated mice after sham surgery or PHx. Panel e shows means ± SD. Data are representative of three independent experiments. Panels a-d, f show means ± SEM. Data are derived from two or three independent experiments with similar results. n = 3–7. N.D., not detected. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001