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Fig. 3 | Military Medical Research

Fig. 3

From: Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

Fig. 3

TLR5 deficiency suppresses hepatocyte priming in PHx-induced liver regeneration. a Relative mRNA levels of hepatic c-fos, c-myc, and c-jun in WT and Tlr5−/− mice at the indicated times after PHx. b Serum TNF-α, IL-6, TGF-α, and HGF were measured in regenerating WT and Tlr5−/− mouse livers. c Quantification of hepatic TNF-α, IL-6, TGF-α, and HGF mRNA expression in WT and Tlr5−/− mice at the indicated times after PHx. d Western blot analysis of the indicated target proteins in WT and Tlr5−/− mouse livers after PHx, with β-actin as the loading control. Panels a and c show means ± SD. Results are representative of three independent experiments. Panel b shows means ± SEM. Data are derived from two or three independent experiments with similar results. n = 4–6. Western blot data in panel d are representative of three independent experiments. N.D., not detected. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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