Table 2 Symptoms, signs, disease severity, laboratory tests and radiographic findings of COVID-19 pneumonia and other viral pneumonia
Measures | COVID-19 pneumonia (n = 40)a | Viral pneumonia (n = 284)a | P |
|---|---|---|---|
Symptoms and signs [n (%)] | |||
 Fever | 22 (55.0) | 221 (77.8) | < 0.001 |
 Duration of fever [d, median (IQR)] | 2.00 (1.00–3.25) | 4.00 (2.00–5.00) | 0.004 |
 Highest temperature [n (%)] | |||
   < 37.3 °C | 18 (45.0) | 63 (22.2) | < 0.001 |
  37.4–37.9 °C | 8 (20.0) | 8 (2.8) | |
  38.0–38.9 °C | 11 (27.5) | 46 (16.2) | |
   > 39.0 °C | 3 (7.5) | 167 (58.8) | |
 Cough [n (%)] | 6 (15.0) | 256 (90.1) | < 0.001 |
 Dry cough [n (%)] | 6 (15.0) | 35 (12.3) | 0.634 |
 Cough with Sputum production [n (%)] | 0 (0.0) | 229 (80.6) | < 0.001 |
 Sore throat [n (%)] | 1 (2.5) | 8 (2.8) | 0.909 |
 Rhinitis [n (%)] | 1 (2.5) | 130 (45.8) | < 0.001 |
 Short of breath [n (%)] | 1 (2.5) | 22 (7.7) | 0.226 |
 Wheezing [n (%)] | 0 (0.0) | 43 (15.1) | 0.017 |
 Gastrointestinal symptoms [n (%)] | 1 (2.5) | 17 (6.0) | 0.709 |
 Fatigue or muscle aches [n (%)] | 1 (2.5) | 12 (4.2) | 0.603 |
 Neurological symptoms [n (%)] | 2 (5.0) | 15 (5.3) | 0.940 |
 Three depression sign [n (%)] | 1 (2.5) | 36 (12.7) | 0.058 |
 Low SaO2 of inhospital (< 95%,n (%)] | 1 (2.5) | 9 (3.2) | 0.819 |
Severity [n (%)] | |||
 Moderate | 39 (97.5) | 246 (86.6) | 0.048 |
 Server or critical | 1 (2.5) | 38 (13.4) | |
Blood routine | |||
 WBC count [×109/L; median (IQR)] | 5.3 (4.4–7.8) | 8.6 (6.3–12.1) | < 0.001 |
   < 5.5 × 109/L [n (%)] | 19 (47.5) | 38 (13.4) | < 0.001 |
 Neutrophil count [× 109/L; median (IQR)] | 2.5 (1.9–3.3) | 3.2 (2.1–4.6) | 0.029 |
   < 1.1 × 109/L [n (%)] | 3 (7.5) | 12 (4.2) | 0.356 |
 Platelet count [×109/L; median (IQR)] | 253.0 (217.3–320.0) | 275.0 (209.0–350.0) | 0.410 |
   < 120 × 109/L [n (%)] | 1 (2.5) | 9 (3.2) | 0.819 |
Inflammatory indicators [n (%)] | |||
 PCT (> 0.25 ng/ml) | 2/34 (5.9) | 78/209 (37.3) | < 0.001 |
 CRP (> 10 mg/L) | 5/38 (13.2) | 80/281 (28.5) | 0.045 |
 ESR (> 20 s) | 5/36 (13.9) | 35/62 (56.5) | < 0.001 |
 IL-6 (> 20.9 ng/L) | 5/34 (14.7) | 62/168 (36.9) | 0.012 |
Blood biochemistry | |||
 LDH [U/L; median (IQR)] | 210.0 (187.0–482.4) | 349.0 (228.5–418.5) | < 0.001 |
   > 300 U/L [n (%)] | 13/26 (36.1) | 131/265 (49.4) | < 0.001 |
 ALT [U/L; median (IQR)] | 12.5 (9.25–24.0) | 17 (13–23) | 0.035 |
   > 45 U/L [n (%)] | 4 (10.0) | 18/275 (6.5) | 0.432 |
 AST [U/L; median (IQR)] | 33.9 (19.8–41.3) | 37.0 (31.0–45.0) | 0.011 |
   > 50 U/L [n (%)] | 4 (10.0) | 36/276 (13.0) | 0.588 |
 CK [U/L; median (IQR)] | 70.0 (57.0–91.8) | 110.5 (79.3–155.8) | < 0.001 |
   > 185 U/L [n (%)] | 2/35 (5.7) | 48/276 (17.4) | 0.076 |
 CK-MB (> 27 U/L) [n (%)] | 5/35 (14.3) | 165/270 (61.1) | < 0.001 |
Humoral immunity [g/L; median (IQR)] | |||
 Ig G | 8.1 (4.8–10.6) | 8.4 (6.9–10.2) | 0.712 |
 Ig M | 1.3 (1.0–1.6) | 1.3 (0.9–1.6) | 0.995 |
 Ig A | 1.0 (0.5–1.3) | 0.9 (0.6–1.4) | 0.218 |
Cellular immunity | |||
 CD4+/CD8+ T cell [median (IQR)] | 1.2 (0.9–1.6) | 1.2 (0.9–1.8) | 0.534 |
   < 0.96 [n (%)] | 6/17 (35.3) | 4/16 (25.0) | 0.479 |
  0.96–2.05 [n (%)] | 10/17 (58.8) | 9/16 (56.2) | |
   > 2.05 [n (%)] | 1/17 (5.9) | 3/16 (18.8) | |
Coagulation | |||
 Fibrinogen [g/L; median (IQR)] | 2.5 (2.4–3.0) | 3.1 (2.4–3.9) | 0.114 |
 D-dimer [mg/L; median (IQR)] | 0.32 (0.25–0.42) | 0.53 (0.33–1.00) | 0.004 |
   > 0.5 mg/L [n (%)] | 7/35 (20.0) | 18/29 (62.1) | 0.001 |
 Prothrombin time [s, median (IQR)] | 11.2 (10.2–13.3) | 11.2 (10.3–13.0) | 0.113 |
 APTT [s, median (IQR)] | 34.7 (31.3–36.4) | 31.6 (25.8–35.7) | 0.111 |
Co-infection [n (%)] | |||
 Virus | 3 (7.5) | 22 (7.7) | 0.956 |
 MP | 9 (22.5) | 61 (21.5) | 0.883 |
Secondary-infection with bacteria [n (%)] | 0 (0.0) | 52 (18.3) | 0.003 |
Affected area on radiography [n (%)]— no. (%) | |||
 Left lung lobe | 5 (12.5) | 18/202 (8.9) | 0.071 |
 Right lung lobe | 14 (35.0) | 41/202 (20.3) | |
 Bilateral lung lobe | 21 (52.5) | 143/202 (70.8) | |
CT images of the chest [n (%)] | |||
 GGO | 18 (45.0) | 0/38 (0.0) | < 0.001 |
 Tiny nodules | 6 (15.0) | 2/38 (5.3) | 0.297 |
 Consolidation | 5 (12.5) | 21/38 (55.3) | < 0.001 |
 Consolidation combined with GGO | 4 (10.0) | 1/38 (2.6) | 0.387 |
 Cable shadow | 11 (27.5) | 18/38 (47.4) | 0.070 |
 Light shadow | 6 (15.0) | 5/38 (13.2) | 0.815 |
 Streak shadow | 6 (15.0) | 6/38 (15.8) | 0.923 |
 Hydrothorax | 1 (2.5) | 1/38 (2.6) | 1.000 |