TY - JOUR AU - Hu, Wei AU - Zhang, Chao AU - Shi, Ji-Jing AU - Zhang, Ji-Yuan AU - Wang, Fu-Sheng PY - 2020 DA - 2020/12/01 TI - Hepatitis C: milestones from discovery to clinical cure JO - Military Medical Research SP - 59 VL - 7 IS - 1 AB - On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for “the discovery of hepatitis C virus (HCV)”. During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the “scientific journey” from the first report of non-A, non-B hepatitis and discovery of the pathogen (HCV) to final identification of efficacious direct-acting antivirals. Further, we address the challenges and unmet issues in this field. SN - 2054-9369 UR - https://doi.org/10.1186/s40779-020-00288-y DO - 10.1186/s40779-020-00288-y ID - Hu2020 ER -