From: Effects and mechanism of platelet-rich plasma on military drill injury: a review
Growth factors | Receptor | Role in tissue repair | References |
---|---|---|---|
HGF | c-Met | Stimulation of multiple cell growth, such as Hepatocytes, endothelial cells, epithelial cells | |
VEGF | VEGFR1(Flt1), VEGFR2(KDR/Flk1) VEGFR3(Flk4) | Stimulation of vascular endothelial cell proliferation and migration, initiation of angiogenesis response | [17] |
TGF-β | TGF-β receptor I TGF-β receptor II | Involvement of inflammatory response, promotio of extracellular matrix secretion, stimulation of bone matrix deposition, inhibition of osteoclast formation and bone absorption | |
IGF | IGF-IR, IGF-IIR | Chemotaxis of fibroblasts, promotion of cartilage and bone matrix formation, stimulation of ESCs proliferation and differentiation | |
EGF | EGFR (ERBB1) | Promotion of re-epithelization and participating in angiogenesis | |
FGFs | FGFR1, FGFR2, FGFR3 | Mitotic stimulation of articular chondrocytes, promotion of wound healing | |
PDGF | PDGFRα, PDGFRβ (αα, αβ, ββ) | Promotion of angiogenesis and activation of macrophages, Stimulation of fibroblasts, vascular smooth muscle cells and Schwann cells proliferation and activity |