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Table 1 The role of growth factors contained in PRP in tissue repair

From: Effects and mechanism of platelet-rich plasma on military drill injury: a review

Growth factors Receptor Role in tissue repair References
HGF c-Met Stimulation of multiple cell growth, such as Hepatocytes, endothelial cells, epithelial cells [13,14,15,16]
VEGF VEGFR1(Flt1),
VEGFR2(KDR/Flk1)
VEGFR3(Flk4)
Stimulation of vascular endothelial cell proliferation and migration, initiation of angiogenesis response [17]
TGF-β TGF-β receptor I
TGF-β receptor II
Involvement of inflammatory response, promotio of extracellular matrix secretion, stimulation of bone matrix deposition, inhibition of osteoclast formation and bone absorption [18, 19]
IGF IGF-IR, IGF-IIR Chemotaxis of fibroblasts, promotion of cartilage and bone matrix formation, stimulation of ESCs proliferation and differentiation [20,21,22,23]
EGF EGFR (ERBB1) Promotion of re-epithelization and participating in angiogenesis [23, 24]
FGFs FGFR1, FGFR2, FGFR3 Mitotic stimulation of articular chondrocytes, promotion of wound healing [25, 26]
PDGF PDGFRα, PDGFRβ
(αα, αβ, ββ)
Promotion of angiogenesis and activation of macrophages, Stimulation of fibroblasts, vascular smooth muscle cells and Schwann cells proliferation and activity [27,28,29]
  1. HGF Hepatocyte growth factor, VEGF Vascular endothelial growth factor, TGF-β Transforming growth factor-β, IGF Insulin-like growth factor, EGF Epidermal growth factor, FGF Fibroblast growth factor, PDGF Platelet-derived growth factor