From: Effects of different plasma expanders on rats subjected to severe acute normovolemic hemodilution
Group | BL | H1 | H2 | H3 | 10 min | 20 min | 30 min | 60 min |
---|---|---|---|---|---|---|---|---|
Systolic blood pressure (SBP) | ||||||||
 Gel | 140.168 ± 11.859 | 136.240 ± 16.364 | 108.203 ± 14.858 | 99.217 ± 12.332(10) | 108.868 ± 16.604 | 116.213 ± 19.754 | 122.789 ± 23.135 | 121.478 ± 32.392(9) |
 HES200 | 139.123 ± 13.148 | 138.648 ± 13.217 | 137.230 ± 13.444(2) | 110.098 ± 20.619(10) | 105.164 ± 20.743 | 125.580 ± 34.151 | 130.991 ± 32.423 | 140.127 ± 40.836(11) |
 HES130 | 138.393 ± 4.859 | 137.778 ± 16.099 | 133.551 ± 13.411(2) | 113.581 ± 17.696(10) | 127.529 ± 21.751 | 126.629 ± 27.639 | 131.209 ± 29.269 | 130.090 ± 33.383 |
 HES40 | 141.577 ± 6.409 | 126.817 ± 13.688 | 115.416 ± 27.967(4) (5) | 86.612 ± 17.932(3) (5) (10) | 93.876 ± 24.222(6) | 115.765 ± 27.760 | 131.297 ± 26.220 | 130.018 ± 35.846(11) |
 Dex40 | 142.231 ± 14.095 | 64.673 ± 14.231(2) (4) (6) (7) | 106.242 ± 20.505(4) (6) | 103.146 ± 24.677(10) | 105.697 ± 27.972 | 109.319 ± 30.351 | 110.334 ± 32.954 | 86.488 ± 43.068(1) (4) (5) (7) (10) |
Diastolic blood pressure (DBP) | ||||||||
 Gel | 94.853 ± 8.881 | 81.576 ± 11.379 | 55.466 ± 9.690 | 46.653 ± 8.872(10) | 46.849 ± 7.914 | 47.318 ± 8.521 | 49.323 ± 11.481 | 43.576 ± 9.762(10) |
 HES200 | 93.682 ± 12.993 | 82.916 ± 9.286 | 74.398 ± 9.178 | 52.788 ± 10.263(10) | 48.952 ± 10.530 | 52.568 ± 11.833 | 51.080 ± 9.613 | 54.891 ± 13.559(10) |
 HES130 | 92.796 ± 6.813 | 76.879 ± 11.935 | 65.290 ± 9.624(1)(3) | 46.919 ± 6.062(10) | 49.234 ± 6.613 | 46.686 ± 8.530 | 50.147 ± 11.068 | 53.093 ± 14.453(10) |
 HES40 | 95.000 ± 7.770 | 75.343 ± 12.010(4) | 58.860 ± 10.754(4) | 42.429 ± 9.303(4)(10) | 39.901 ± 9.207(3) (5) | 43.588 ± 8.055(5) | 47.657 ± 4.737 | 44.543 ± 9.174(10) |
 Dex40 | 95.284 ± 11.680 | 38.584 ± 6.161(2) (4) (6) (8) | 59.405 ± 9.050(4) | 48.187 ± 6.088(10) | 41.532 ± 4.152 | 41.864 ± 8.027(3) | 39.731 ± 7.165(1) (3) (5) | 37.158 ± 7.677(2) (4) (6) (10) |
Mean arterial pressure (MAP) | ||||||||
 Gel | 111.752 ± 8.667 | 100.658 ± 10.970 | 75.215 ± 11.170 | 64.753 ± 9.945(10) | 65.321 ± 8.045 | 67.178 ± 9.241 | 68.885 ± 10.102 | 63.618 ± 14.470(10) |
 HES200 | 113.651 ± 9.458 | 106.256 ± 7.667 | 97.344 ± 9.185(2) | 74.505 ± 13.152(1) (10) | 67.913 ± 13.060 | 73.728 ± 14.269 | 74.898 ± 10.664 | 75.712 ± 13.547(10) |
 HES130 | 109.871 ± 7.333 | 97.837 ± 9.597 | 90.348 ± 5.013(2) | 68.081 ± 5.942(10) | 71.926 ± 5.203 | 68.477 ± 9.812 | 71.109 ± 11.126 | 70.802 ± 13.674(10) |
 HES40 | 112.675 ± 6.884 | 92.496 ± 12.882(4) | 78.461 ± 15.922(4) (5) | 59.537 ± 12.138(4) (10) | 57.265 ± 10.350(3) (6) | 66.001 ± 6.237 | 71.123 ± 6.282 | 66.339 ± 11.590(4) (10) |
 Dex40 | 115.122 ± 7.716 | 47.732 ± 7.961(2) (4) (6) (8) | 76.580 ± 12.221(3) (6) | 68.285 ± 9.118(10) | 59.605 ± 5.867(5) | 63.803 ± 14.947(3) | 57.754 ± 8.092(1) (4) (5) (8) | 47.899 ± 15.187(2) (3) (4) (6) (10) (12) |
Pulse pressure (PP) | ||||||||
 Gel | 94.853 ± 8.881 | 81.576 ± 11.379 | 55.466 ± 9.690 | 46.653 ± 8.872(9) | 46.849 ± 7.914 | 47.318 ± 8.521 | 49.323 ± 11.481 | 43.576 ± 9.762(10) (11) |
 HES200 | 93.682 ± 12.993 | 82.916 ± 9.286 | 74.398 ± 9.178 | 52.788 ± 10.263(9) | 48.952 ± 10.530 | 52.568 ± 11.833 | 51.080 ± 9.613 | 54.891 ± 13.559(9) |
 HES130 | 92.796 ± 6.813 | 76.879 ± 11.935 | 65.290 ± 9.624 | 46.919 ± 6.062(10) | 49.234 ± 6.613 | 46.686 ± 8.530 | 50.147 ± 11.068 | 53.093 ± 14.453 |
 HES40 | 95.000 ± 7.770 | 75.343 ± 12.010 | 58.860 ± 10.754 | 42.429 ± 9.303 | 39.901 ± 9.207(5) | 43.588 ± 8.055 | 47.657 ± 4.737 | 44.543 ± 9.174(10) (11) |
 Dex40 | 95.284 ± 11.680 | 38.584 ± 6.161(2)(4)(6)(8) | 59.405 ± 9.050 | 48.187 ± 6.088 | 41.532 ± 4.152 | 41.864 ± 8.027 | 39.731 ± 7.165 | 37.158 ± 7.677(3) |
Heart rate (HR) | ||||||||
 Gel | 420.289 ± 53.954 | 434.743 ± 52.869 | 394.134 ± 57.146 | 410.907 ± 26.481 | 407.544 ± 5.332 | 426.433 ± 10.575 | 444.577 ± 18.442 | 475.540 ± 24.602(10) (12) |
 HES200 | 427.301 ± 37.580 | 418.391 ± 38.261 | 434.958 ± 32.169 | 422.450 ± 42.006 | 384.181 ± 46.764 | 403.069 ± 41.881 | 413.515 ± 42.572 | 444.300 ± 42.493 |
 HES130 | 385.530 ± 43.569 | 409.406 ± 40.672 | 418.329 ± 44.260 | 420.304 ± 37.465 | 420.787 ± 35.688 | 430.079 ± 30.444 | 415.786 ± 48.098 | 479.939 ± 53.086(10) (12) |
 HES40 | 430.198 ± 29.904 | 424.210 ± 43.051 | 424.833 ± 36.148 | 401.392 ± 50.950 | 408.080 ± 55.381 | 441.905 ± 58.796 | 453.675 ± 51.001 | 486.037 ± 32.176(10) (12) |
 Dex40 | 392.847 ± 33.640 | 420.452 ± 63.136 | 439.580 ± 15.382(1) | 460.738 ± 28.251(1)(7)(10) | 471.792 ± 44.495(2) (4) (5) (8) | 476.878 ± 47.590(2) (4) (5) | 479.893 ± 45.129(4) (6) | 475.450 ± 31.951(10) |