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Table 1 The physiological parameters of rats that underwent ANH at different times with different plasma expanders (\( \overline{x}\pm s \), n = 12)

From: Effects of different plasma expanders on rats subjected to severe acute normovolemic hemodilution

Group

BL

H1

H2

H3

10 min

20 min

30 min

60 min

Systolic blood pressure (SBP)

 Gel

140.168 ± 11.859

136.240 ± 16.364

108.203 ± 14.858

99.217 ± 12.332(10)

108.868 ± 16.604

116.213 ± 19.754

122.789 ± 23.135

121.478 ± 32.392(9)

 HES200

139.123 ± 13.148

138.648 ± 13.217

137.230 ± 13.444(2)

110.098 ± 20.619(10)

105.164 ± 20.743

125.580 ± 34.151

130.991 ± 32.423

140.127 ± 40.836(11)

 HES130

138.393 ± 4.859

137.778 ± 16.099

133.551 ± 13.411(2)

113.581 ± 17.696(10)

127.529 ± 21.751

126.629 ± 27.639

131.209 ± 29.269

130.090 ± 33.383

 HES40

141.577 ± 6.409

126.817 ± 13.688

115.416 ± 27.967(4) (5)

86.612 ± 17.932(3) (5) (10)

93.876 ± 24.222(6)

115.765 ± 27.760

131.297 ± 26.220

130.018 ± 35.846(11)

 Dex40

142.231 ± 14.095

64.673 ± 14.231(2) (4) (6) (7)

106.242 ± 20.505(4) (6)

103.146 ± 24.677(10)

105.697 ± 27.972

109.319 ± 30.351

110.334 ± 32.954

86.488 ± 43.068(1) (4) (5) (7) (10)

Diastolic blood pressure (DBP)

 Gel

94.853 ± 8.881

81.576 ± 11.379

55.466 ± 9.690

46.653 ± 8.872(10)

46.849 ± 7.914

47.318 ± 8.521

49.323 ± 11.481

43.576 ± 9.762(10)

 HES200

93.682 ± 12.993

82.916 ± 9.286

74.398 ± 9.178

52.788 ± 10.263(10)

48.952 ± 10.530

52.568 ± 11.833

51.080 ± 9.613

54.891 ± 13.559(10)

 HES130

92.796 ± 6.813

76.879 ± 11.935

65.290 ± 9.624(1)(3)

46.919 ± 6.062(10)

49.234 ± 6.613

46.686 ± 8.530

50.147 ± 11.068

53.093 ± 14.453(10)

 HES40

95.000 ± 7.770

75.343 ± 12.010(4)

58.860 ± 10.754(4)

42.429 ± 9.303(4)(10)

39.901 ± 9.207(3) (5)

43.588 ± 8.055(5)

47.657 ± 4.737

44.543 ± 9.174(10)

 Dex40

95.284 ± 11.680

38.584 ± 6.161(2) (4) (6) (8)

59.405 ± 9.050(4)

48.187 ± 6.088(10)

41.532 ± 4.152

41.864 ± 8.027(3)

39.731 ± 7.165(1) (3) (5)

37.158 ± 7.677(2) (4) (6) (10)

Mean arterial pressure (MAP)

 Gel

111.752 ± 8.667

100.658 ± 10.970

75.215 ± 11.170

64.753 ± 9.945(10)

65.321 ± 8.045

67.178 ± 9.241

68.885 ± 10.102

63.618 ± 14.470(10)

 HES200

113.651 ± 9.458

106.256 ± 7.667

97.344 ± 9.185(2)

74.505 ± 13.152(1) (10)

67.913 ± 13.060

73.728 ± 14.269

74.898 ± 10.664

75.712 ± 13.547(10)

 HES130

109.871 ± 7.333

97.837 ± 9.597

90.348 ± 5.013(2)

68.081 ± 5.942(10)

71.926 ± 5.203

68.477 ± 9.812

71.109 ± 11.126

70.802 ± 13.674(10)

 HES40

112.675 ± 6.884

92.496 ± 12.882(4)

78.461 ± 15.922(4) (5)

59.537 ± 12.138(4) (10)

57.265 ± 10.350(3) (6)

66.001 ± 6.237

71.123 ± 6.282

66.339 ± 11.590(4) (10)

 Dex40

115.122 ± 7.716

47.732 ± 7.961(2) (4) (6) (8)

76.580 ± 12.221(3) (6)

68.285 ± 9.118(10)

59.605 ± 5.867(5)

63.803 ± 14.947(3)

57.754 ± 8.092(1) (4) (5) (8)

47.899 ± 15.187(2) (3) (4) (6) (10) (12)

Pulse pressure (PP)

 Gel

94.853 ± 8.881

81.576 ± 11.379

55.466 ± 9.690

46.653 ± 8.872(9)

46.849 ± 7.914

47.318 ± 8.521

49.323 ± 11.481

43.576 ± 9.762(10) (11)

 HES200

93.682 ± 12.993

82.916 ± 9.286

74.398 ± 9.178

52.788 ± 10.263(9)

48.952 ± 10.530

52.568 ± 11.833

51.080 ± 9.613

54.891 ± 13.559(9)

 HES130

92.796 ± 6.813

76.879 ± 11.935

65.290 ± 9.624

46.919 ± 6.062(10)

49.234 ± 6.613

46.686 ± 8.530

50.147 ± 11.068

53.093 ± 14.453

 HES40

95.000 ± 7.770

75.343 ± 12.010

58.860 ± 10.754

42.429 ± 9.303

39.901 ± 9.207(5)

43.588 ± 8.055

47.657 ± 4.737

44.543 ± 9.174(10) (11)

 Dex40

95.284 ± 11.680

38.584 ± 6.161(2)(4)(6)(8)

59.405 ± 9.050

48.187 ± 6.088

41.532 ± 4.152

41.864 ± 8.027

39.731 ± 7.165

37.158 ± 7.677(3)

Heart rate (HR)

 Gel

420.289 ± 53.954

434.743 ± 52.869

394.134 ± 57.146

410.907 ± 26.481

407.544 ± 5.332

426.433 ± 10.575

444.577 ± 18.442

475.540 ± 24.602(10) (12)

 HES200

427.301 ± 37.580

418.391 ± 38.261

434.958 ± 32.169

422.450 ± 42.006

384.181 ± 46.764

403.069 ± 41.881

413.515 ± 42.572

444.300 ± 42.493

 HES130

385.530 ± 43.569

409.406 ± 40.672

418.329 ± 44.260

420.304 ± 37.465

420.787 ± 35.688

430.079 ± 30.444

415.786 ± 48.098

479.939 ± 53.086(10) (12)

 HES40

430.198 ± 29.904

424.210 ± 43.051

424.833 ± 36.148

401.392 ± 50.950

408.080 ± 55.381

441.905 ± 58.796

453.675 ± 51.001

486.037 ± 32.176(10) (12)

 Dex40

392.847 ± 33.640

420.452 ± 63.136

439.580 ± 15.382(1)

460.738 ± 28.251(1)(7)(10)

471.792 ± 44.495(2) (4) (5) (8)

476.878 ± 47.590(2) (4) (5)

479.893 ± 45.129(4) (6)

475.450 ± 31.951(10)

  1. (1) P < 0.05, (2) P < 0.01 compared with Gel; (3) P < 0.05, (4) P < 0.01 compared with HES200; (5) P < 0.05, (6) P < 0.01 compared with HES130; (7) P < 0.05, (8) P < 0.01 compared with HES40; (9) P < 0.05, (10) P < 0.01 compared with BL; (11) P < 0.05, (12) P < 0.01 compared with H3