Table 2 Risk factors associated with acute kidney dysfunction in traumatic rhabdomyolysis
From: Acute kidney injury in severely injured patients admitted to the intensive care unit
Variables | Simple logistic regressions | Multivariable logistic regressiona | ||
|---|---|---|---|---|
OR (95%CI) | P | OR (95%CI) | P | |
Demographics | ||||
Age (for every 10 years) | 1.16 (0.98–1.38) | 0.083 | 1.30 (1.06–1.60) | 0.01 |
Gender | ||||
Male | 0.53 (0.2–1.31) | 0.167 | – | |
Female | – | |||
Trauma mechanism | ||||
Blast | – | 0.334 (0.10–1.12) | 0.08 | |
Penetrating | 3.56 (1.21–10.48) | 0.022 | ||
Blunt | 4.83 (1.59–14.71) | 0.006 | ||
Severity scores | ||||
RTS | 0.82 (0.69–0.98) | 0.026 | – | |
ISS | 1.04 (1.01–1.06) | 0.003 | – | |
AIS head & neck | 0.89 (0.78–1.03) | 0.118 | – | |
AIS face | 0.78 (0.59–1.02) | 0.068 | – | |
AIS thorax | 1.30 (1.12–1.51) | < 0.001 | 1.23 (1.04–1.46) | 0.02 |
AIS abdomen/pelvis | 1.23 (1.06–1.43) | 0.006 | – | |
AIS extremity | 1.09 (0.93–1.29) | 0.293 | – | |
AIS external | 0.71 (0.50–1.00) | 0.052 | – | |
APACHE II | 1.08 (1.05–1.12) | < 0.01 | 1.05 (1.01–1.09) | 0.03 |
Biochemical markers | ||||
Initial lactic acid | 1.23 (1.11–1.36) | < 0.001 | 1.17 (1.03–1.33) | 0.02 |
Initial base deficit | 1.12 (1.06–1.19) | < 0.01 | – | |
Higher CK | 1.00 (0.99–1.0) | 0.12 | – | |
CK > 5000 U/L | 2.35 (1.29–4.31) | < 0.01 | 2.64 (1.31–5.33) | < 0.001 |
Resuscitation & nephrotoxic agents | ||||
Fluid balance, first day | 1.16 (1.06–1.27) | < 0.01 | – | |
Fluid balance 72 h | 1.20 (1.12–1.28) | < 0.01 | – | |
Packed red blood cells, first day | 1.09 (1.02–1.17) | 0.011 | – | |
FFP transfusion | 2.28 (1.31–3.98) | < 0.01 | – | |
Bicarbonate administration | 2.4 (1.96–5.44) | 0.035 | – | |
Contrast administration | 1.43 (0.80–2.54) | 0.23 | – | |
Contrast dose ×100 mg | 1.32 (1.04–1.67) | 0.02 | – | |
Norepinephrine administration | 2.42 (1.42–4.1) | < 0.01 | – | |
Vasopressin administration | 1.59 (0.79–3.19) | 0.19 | – | |
Dobutamine administration | 4.37 (1.74–11.0) | < 0.01 | 3.16 (1.01–9.94) | 0.049 |