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Table 7 Distribution of rs6756667 and rs3025039 in study subjects

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Subgroup Multiple SNPs AMS group (n = 318) Non-AMS group (n = 284) OR (95% CI) P-value OR (95% CI)a P-valuea
EPAS1-rs6756667 VEGFA-rs3025039
1 GA/AA CC 37 (11.7) 64 (22.7) 1   1  
2 GA/AA CT/TT 20 (6.2) 15 (5.4) 2.31 (1.06–5.04) 0.036* 2.35 (1.07–5.17) 0.033*
3 GG CC 177 (56.5) 151 (52.9) 2.03 (1.28–3.21) 0.003* 2.06 (1.30–3.27) 0.002*
4 GG CT /TT 84 (25.6) 54 (19.0) 2.69 (1.58–4.57) < 0.001* 2.70 (1.59–4.61) < 0.001*
  1. Subgroup 1: Subjects carrying neither rs6756667 “GG” genotype nor rs3025039 “CT/TT” genotype; Subgroup 2: Subjects carrying rs3025039 “CT/TT” genotype but no rs6756667 “GG” genotype; Subgroup 3: Subjects carrying rs6756667 “GG” genotype but no rs3025039 “CT/TT” genotype; Subgroup 4: Subjects carrying both rs3025039 “CT/TT” genotype and rs6756667 “GG” genotype. Two subjects were excluded because the genotyping results of VEGFA-rs3025039 were missing. a adjusted for age, BMI and smoking status; * P < 0.05 indicated significant difference. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; OR Odds ratio; CI Confidence interval