Subgroup | Multiple SNPs | AMS group (n = 318) | Non-AMS group (n = 284) | OR (95% CI) | P-value | OR (95% CI)a | P-valuea |
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EPAS1-rs6756667 | VEGFA-rs3025039 |
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1 | GA/AA | CC | 37 (11.7) | 64 (22.7) | 1 | | 1 | |
2 | GA/AA | CT/TT | 20 (6.2) | 15 (5.4) | 2.31 (1.06–5.04) | 0.036* | 2.35 (1.07–5.17) | 0.033* |
3 | GG | CC | 177 (56.5) | 151 (52.9) | 2.03 (1.28–3.21) | 0.003* | 2.06 (1.30–3.27) | 0.002* |
4 | GG | CT /TT | 84 (25.6) | 54 (19.0) | 2.69 (1.58–4.57) | < 0.001* | 2.70 (1.59–4.61) | < 0.001* |
- Subgroup 1: Subjects carrying neither rs6756667 “GG” genotype nor rs3025039 “CT/TT” genotype; Subgroup 2: Subjects carrying rs3025039 “CT/TT” genotype but no rs6756667 “GG” genotype; Subgroup 3: Subjects carrying rs6756667 “GG” genotype but no rs3025039 “CT/TT” genotype; Subgroup 4: Subjects carrying both rs3025039 “CT/TT” genotype and rs6756667 “GG” genotype. Two subjects were excluded because the genotyping results of VEGFA-rs3025039 were missing. a adjusted for age, BMI and smoking status; * P < 0.05 indicated significant difference. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; OR Odds ratio; CI Confidence interval