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Table 7 Distribution of rs6756667 and rs3025039 in study subjects

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Subgroup

Multiple SNPs

AMS group (n = 318)

Non-AMS group (n = 284)

OR (95% CI)

P-value

OR (95% CI)a

P-valuea

EPAS1-rs6756667

VEGFA-rs3025039

1

GA/AA

CC

37 (11.7)

64 (22.7)

1

 

1

 

2

GA/AA

CT/TT

20 (6.2)

15 (5.4)

2.31 (1.06–5.04)

0.036*

2.35 (1.07–5.17)

0.033*

3

GG

CC

177 (56.5)

151 (52.9)

2.03 (1.28–3.21)

0.003*

2.06 (1.30–3.27)

0.002*

4

GG

CT /TT

84 (25.6)

54 (19.0)

2.69 (1.58–4.57)

< 0.001*

2.70 (1.59–4.61)

< 0.001*

  1. Subgroup 1: Subjects carrying neither rs6756667 “GG” genotype nor rs3025039 “CT/TT” genotype; Subgroup 2: Subjects carrying rs3025039 “CT/TT” genotype but no rs6756667 “GG” genotype; Subgroup 3: Subjects carrying rs6756667 “GG” genotype but no rs3025039 “CT/TT” genotype; Subgroup 4: Subjects carrying both rs3025039 “CT/TT” genotype and rs6756667 “GG” genotype. Two subjects were excluded because the genotyping results of VEGFA-rs3025039 were missing. a adjusted for age, BMI and smoking status; * P < 0.05 indicated significant difference. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; OR Odds ratio; CI Confidence interval