EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Table 5 Associations analyses between PPARA-rs7292407 and AMS

Model	Allele/Genotype	AMS group (n = 320)	Non-AMS group (n = 284)	OR (95% CI)	P-value	OR (95% CI)^a	P-value^a	Q-value
Allele	C	524 (87.3)	445 (82.1)	–	0.014*	–	–	–
Allele	A	76 (12.7)	97 (17.9)	–		–
Codominant	CC	230 (76.7)	187 (69.0)	1	0.050	1	0.068	0.313
	AC	64 (21.3)	71 (26.2)	0.73 (0.50–1.08)		0.73 (0.50–1.09)
	AA	6 (2.0)	13 (4.8)	0.38 (0.14–1.01)		0.40 (0.15–1.07)
Dominant	CC	230 (76.7)	187 (69.0)	1	0.039*	1	0.046*	0.265
Dominant	AC/AA	70 (23.3)	84 (31.0)	0.68 (0.47–0.98)		0.68 (0.47–0.99)
Recessive	CC/AC	294 (98.0)	258 (95.2)	1	0.061	1	0.083	0.318
Recessive	AA	6 (2.0)	13 (4.8)	0.41 (0.15–1.08)		0.43 (0.16–1.16)

^a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval

ISSN: 2054-9369