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Table 5 Associations analyses between PPARA-rs7292407 and AMS

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Model Allele/Genotype AMS group (n = 320) Non-AMS group (n = 284) OR (95% CI) P-value OR (95% CI)a P-valuea Q-value
Allele C 524 (87.3) 445 (82.1) 0.014*
A 76 (12.7) 97 (17.9)    
Codominant CC 230 (76.7) 187 (69.0) 1 0.050 1 0.068 0.313
AC 64 (21.3) 71 (26.2) 0.73 (0.50–1.08)   0.73 (0.50–1.09)   
AA 6 (2.0) 13 (4.8) 0.38 (0.14–1.01)   0.40 (0.15–1.07)   
Dominant CC 230 (76.7) 187 (69.0) 1 0.039* 1 0.046* 0.265
AC/AA 70 (23.3) 84 (31.0) 0.68 (0.47–0.98)   0.68 (0.47–0.99)   
Recessive CC/AC 294 (98.0) 258 (95.2) 1 0.061 1 0.083 0.318
AA 6 (2.0) 13 (4.8) 0.41 (0.15–1.08)   0.43 (0.16–1.16)   
  1. a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval