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Table 4 Associations analyses between VEGFA-rs3025039 and AMS

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Model

Allele/Genotype

AMS group (n = 320)

Non-AMS group (n = 284)

OR (95% CI)

P-value

OR (95% CI)a

P-valuea

Q-value

Allele

C

523 (82.2)

497 (87.5)

0.011*

T

113 (17.8)

71 (12.5)

 

  

Codominant

CC

214 (67.3)

215 (75.7)

1

0.021*

1

0.022*

0.253

CT

95 (29.9)

67 (23.6)

1.42 (0.99–2.05)

 

1.42 (0.98–2.05)

  

TT

9 (2.8)

2 (0.7)

4.52 (0.97–21.17)

 

4.56 (0.97–21.49)

  

Dominant

CC

214 (67.3)

215 (75.7)

1

0.022*

1

0.024*

0.184

CT/TT

104 (32.7)

69 (24.3)

1.51 (1.06–2.17)

 

1.51 (1.05–2.16)

  

Recessive

CT/CC

309 (97.2)

282 (99.3)

1

0.042

1

0.042

0.483

TT

9 (2.8)

2 (0.7)

4.11 (0.88–19.16)

 

4.15 (0.88–19.48)

  
  1. a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval