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Table 4 Associations analyses between VEGFA-rs3025039 and AMS

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Model Allele/Genotype AMS group (n = 320) Non-AMS group (n = 284) OR (95% CI) P-value OR (95% CI)a P-valuea Q-value
Allele C 523 (82.2) 497 (87.5) 0.011*
T 113 (17.8) 71 (12.5)    
Codominant CC 214 (67.3) 215 (75.7) 1 0.021* 1 0.022* 0.253
CT 95 (29.9) 67 (23.6) 1.42 (0.99–2.05)   1.42 (0.98–2.05)   
TT 9 (2.8) 2 (0.7) 4.52 (0.97–21.17)   4.56 (0.97–21.49)   
Dominant CC 214 (67.3) 215 (75.7) 1 0.022* 1 0.024* 0.184
CT/TT 104 (32.7) 69 (24.3) 1.51 (1.06–2.17)   1.51 (1.05–2.16)   
Recessive CT/CC 309 (97.2) 282 (99.3) 1 0.042 1 0.042 0.483
TT 9 (2.8) 2 (0.7) 4.11 (0.88–19.16)   4.15 (0.88–19.48)   
  1. a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval