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Table 3 Associations analyses between EPAS1-rs6756667 and AMS

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Model Allele/Genotype AMS group (n = 320) Non-AMS group (n = 284) OR (95% CI) P-value OR (95% CI)a P-valuea Q-value
Allele G 583 (91.1) 483 (85.0) 0.001*
A 57 (8.9) 85 (15.0)    
Codominant GG 263 (82.2) 205 (72.2) 1 < 0.001* 1 0.0005* 0.012*
GA 57 (17.8) 73 (25.7) 0.61 (0.41–0.90)   0.60 (0.41–0.90)   
AA 0 (0.0) 6 (2.1) 0.00 (0.00-NA)   0.00 (0.00-NA)   
Dominant GG 263 (82.2) 205 (72.2) 1 0.003* 1 0.003* 0.069
GA/AA 57 (17.8) 79 (27.8) 0.56 (0.38–0.83)   0.56 (0.38–0.82)   
Recessive GA/GG 320 (100.0) 278 (97.9) 1 0.003* 1 0.003* 0.069
AA 0 (0.0) 6 (2.1) 0.00 (0.00-NA)   0.00 (0.00-NA)   
  1. a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval