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Table 3 Associations analyses between EPAS1-rs6756667 and AMS

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Model

Allele/Genotype

AMS group (n = 320)

Non-AMS group (n = 284)

OR (95% CI)

P-value

OR (95% CI)a

P-valuea

Q-value

Allele

G

583 (91.1)

483 (85.0)

0.001*

A

57 (8.9)

85 (15.0)

 

  

Codominant

GG

263 (82.2)

205 (72.2)

1

< 0.001*

1

0.0005*

0.012*

GA

57 (17.8)

73 (25.7)

0.61 (0.41–0.90)

 

0.60 (0.41–0.90)

  

AA

0 (0.0)

6 (2.1)

0.00 (0.00-NA)

 

0.00 (0.00-NA)

  

Dominant

GG

263 (82.2)

205 (72.2)

1

0.003*

1

0.003*

0.069

GA/AA

57 (17.8)

79 (27.8)

0.56 (0.38–0.83)

 

0.56 (0.38–0.82)

  

Recessive

GA/GG

320 (100.0)

278 (97.9)

1

0.003*

1

0.003*

0.069

AA

0 (0.0)

6 (2.1)

0.00 (0.00-NA)

 

0.00 (0.00-NA)

  
  1. a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval