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Table 2 Associations analyses between EGLN1-rs2153364 and AMS

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Model Allele/Genotype AMS group (n = 320) Non-AMS group (n = 284) OR (95% CI) P-value OR (95% CI)a P-valuea Q-value
Allele A 285 (49.3) 288 (55.4) 0.044*
G 293 (50.7) 232 (44.6)    
Codominant AA 69 (23.9) 84 (32.3) 1 0.085 1 0.068 0.391
AG 147 (50.9) 120 (46.2) 1.49 (1.00–2.22)   1.53 (1.02–2.29)   
GG 73 (25.2) 56 (21.5) 1.59 (0.99–2.54)   1.62 (1.01–2.61)   
Dominant AA 69 (23.9) 84 (32.3) 1 0.028* 1 0.021* 0.242
AG/GG 220 (76.1) 176 (67.7) 1.52 (1.05–2.21)   1.56 (1.07–2.28)   
Recessive AA/AG 216 (74.7) 204 (78.5) 1 0.300 1 0.300 0.531
GG 73 (25.3) 56 (21.5) 1.23 (0.83–1.83)   1.23 (0.83–1.84)   
  1. a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval