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Table 2 Associations analyses between EGLN1-rs2153364 and AMS

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Model

Allele/Genotype

AMS group (n = 320)

Non-AMS group (n = 284)

OR (95% CI)

P-value

OR (95% CI)a

P-valuea

Q-value

Allele

A

285 (49.3)

288 (55.4)

0.044*

G

293 (50.7)

232 (44.6)

 

  

Codominant

AA

69 (23.9)

84 (32.3)

1

0.085

1

0.068

0.391

AG

147 (50.9)

120 (46.2)

1.49 (1.00–2.22)

 

1.53 (1.02–2.29)

  

GG

73 (25.2)

56 (21.5)

1.59 (0.99–2.54)

 

1.62 (1.01–2.61)

  

Dominant

AA

69 (23.9)

84 (32.3)

1

0.028*

1

0.021*

0.242

AG/GG

220 (76.1)

176 (67.7)

1.52 (1.05–2.21)

 

1.56 (1.07–2.28)

  

Recessive

AA/AG

216 (74.7)

204 (78.5)

1

0.300

1

0.300

0.531

GG

73 (25.3)

56 (21.5)

1.23 (0.83–1.83)

 

1.23 (0.83–1.84)

  
  1. a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval