Inhibitory protein | Function | Complementary receptors |
---|---|---|
Nogo-A | Remyelination inhibitor via the RhoA pathway | Nogo-66 terminus: NgR1, p75, TROY and LINGO1 Amino-Nogo terminus: unknown |
MAG | Remyelination inhibitor via the RhoA pathway | NgR2, GT1b, NgR1, p75, TROY and LINGO1 |
OMgp | Remyelination inhibitor via the RhoA pathway | NgR1 |
Versican (CSPG2) | Important during inflammation as it interacts with inflammatory leukocytes and inflammatory cells recruiting chemokines. It also stabilizes perineuronal nets to stabilize synaptic connections. | N-terminus: hyaluronan in the extracellular matrix (ECM) C-terminus: Ligands in ECM, especially tenascin [75] |
NI-35 | Nonpermissive growth factor in myelin | Unknown |
Ephrin B3 [71] | Inhibits remyelination | EphA4 |
Semaphorin 4D (Sema 4D) [71] | Inhibits remyelination | PlexinB1 |
In scars in both PNS and CNS injuries | Nrp1, Nrp2, L1cam, Nrcam [79] |