Fig. 2From: Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjuryCascade of reactions from a calcium burst and methods of activating regeneration-associated genes (RAGs). MAPKKK dlk1. Mitogen-activated protein kinase kinase kinase dlk-1; pErk. Phosphorylated extracellular signal-regulated protein kinases; HDAC5. Histone Deacetylase 5; RAGs. Regeneration associated genes; PTEN. Phosphatase and tensin homolog; PI3K. Phosphoinositide 3-kinases; AKT. Protein kinase B; mTORC1. Mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1; SOCS3. Suppressor of cytokine signaling 3; JAK/STAT 3. Janus kinase/signal transducer and activator of transcription 3Back to article page