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Table 2 Liver function of the patients with COVID-19 during hospitalization [n (%)].

From: Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients

ItemOverallMild groupSevere groupP-value
ALT(n = 105)(n = 79)(n = 26)0.026
< 1 × ULN65 (61.9)54 (68.4)11 (42.3) 
1–2 × ULN25 (23.8)17 (21.5)8 (30.8) 
2–3 × ULN8 (7.6)3 (3.8)5 (19.2) 
≥3 × ULN7 (6.7)5 (6.3)2 (7.7) 
AST(n = 97)(n = 72)(n = 25)0.001
< 1 × ULN64 (66.0)55 (76.4)9 (36.0) 
1–2 × ULN24 (24.7)13 (18.1)11 (44.0) 
2–3 × ULN7 (7.2)3 (4.2)4 (16.0) 
≥3 × ULN2 (2.1)1 (1.4)1 (4.0) 
TBil(n = 97)(n = 72)(n = 25)0.010
< 1 × ULN73 (75.3)57 (79.2)16 (64.0) 
1–2 × ULN20 (20.6)15 (20.8)5 (20.0) 
2–3 × ULN2 (2.1)0 (0)2 (8.0) 
≥3 × ULN2 (2.1)0 (0)2 (8.0) 
ALT + AST(n = 105)(n = 79)(n = 26)0.001
< 1 × ULN83 (79.0)69 (87.3)14 (53.8) 
1–2 × ULN17 (16.2)8 (10.1)9 (34.6) 
2–3 × ULN3 (2.9)2 (2.5)1 (3.9) 
≥3 × ULN2 (1.9)0 (0)2 (7.7) 
ALT + TBil a(n = 105)(n = 79)(n = 26)0.001
< 1 × ULN96 (91.4)77 (97.5)19 (73.1) 
1–2 × ULN8 (7.6)2 (2.5)6 (23.1) 
2–3 × ULN1 (1.0)0 (0)1 (3.8) 
AST + TBil a(n = 97)(n = 72)(n = 25)< 0.001
< 1 × ULN88 (90.7)71 (98.6)17 (68.0) 
1–2 × ULN7 (7.2)1 (1.4)6 (24.0) 
2–3 × ULN2 (2.1)0 (0)2 (8.0) 
ALT + AST + TBil a(n = 105)(n = 79)(n = 26)< 0.001
< 1 × ULN97 (92.4)78 (98.7)19 (73.1) 
1–2 × ULN7 (6.7)1 (1.3)6 (23.1) 
2–3 × ULN1 (1.0)0 (0)1 (3.8) 
ALT/AST/TBil(n = 105)(n = 79)(n = 26)0.017
< 1 × ULN46 (43.8)38 (48.1)8 (30.8) 
1–2 × ULN40 (38.1)32 (40.5)8 (30.8) 
2–3 × ULN10 (9.5)4 (5.1)6 (23.1) 
≥3 × ULN9 (8.6)5 (6.3)4 (15.4) 
  1. ALT alanine aminotransferase, AST aspartate aminotransferase, TBil total bilirubin
  2. a: In this category, the number of cases that meet the index level > 3 × ULN is 0