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Table 1 Selection of previous studies on ex vivo perfusion in solid organs and extremities

From: Ex vivo limb perfusion for traumatic amputation in military medicine

Working group

Year of publication

Characteristics

Warnecke et al. (Hannover, Germany) [14]

2012

Pilot study on the human application of normothermic EVP in lung transplantation

Warnecke et al. (Hannover, Germany) [15]

2018

Results of the first randomized trial on the human application of normothermic EVP in lung transplantation

Nasralla et al. (United Kingdom) [16]

2018

Results of the first randomized trial on normothermic EVLP in liver transplantation

Constantinescu et al. (Bern, Switzerland) [18]

2011

Feasibility study of EVLP in a porcine model, 16 porcine forelimbs perfused for up to 12 h

Müller et al. (Bern, Switzerland) [19]

2013

EVLP in a porcine model, 64 forelimbs perfused for up to 12 h, replantation surgery was feasible without an increased risk for IRI

Kueckelhaus et al. (Boston, USA) [20]

2017

Developed a prototype hypothermic EVLP device, perfusion for 12 h with consecutive replantation in a porcine model

Ozer et al. (Ann Arbor, USA) [21]

2016

Porcine model with 20 pigs and EVLP up to 24 h, feasibility of extended limb survival with normothermic EVLP

Werner et al. (Ann Arbor, USA) [23]

2017

Near-normothermic EVLP in five human arms from organ donors for 24 h with shown tissue viability

Krezdorn et al. (Boston, USA; Hannover, Germany) [24]

2018

Normothermic EVLP in 8 porcine forelimbs for up to 12 h with subsequent replantation, notably lower expression of hypoxia-related genes in EVLP cohort

  1. EVP ex vivo perfusion, EVLP ex vivo limb perfusion, IRI ischemia-reperfusion injury