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Table 1 Selection of previous studies on ex vivo perfusion in solid organs and extremities

From: Ex vivo limb perfusion for traumatic amputation in military medicine

Working groupYear of publicationCharacteristics
Warnecke et al. (Hannover, Germany) [14]2012Pilot study on the human application of normothermic EVP in lung transplantation
Warnecke et al. (Hannover, Germany) [15]2018Results of the first randomized trial on the human application of normothermic EVP in lung transplantation
Nasralla et al. (United Kingdom) [16]2018Results of the first randomized trial on normothermic EVLP in liver transplantation
Constantinescu et al. (Bern, Switzerland) [18]2011Feasibility study of EVLP in a porcine model, 16 porcine forelimbs perfused for up to 12 h
Müller et al. (Bern, Switzerland) [19]2013EVLP in a porcine model, 64 forelimbs perfused for up to 12 h, replantation surgery was feasible without an increased risk for IRI
Kueckelhaus et al. (Boston, USA) [20]2017Developed a prototype hypothermic EVLP device, perfusion for 12 h with consecutive replantation in a porcine model
Ozer et al. (Ann Arbor, USA) [21]2016Porcine model with 20 pigs and EVLP up to 24 h, feasibility of extended limb survival with normothermic EVLP
Werner et al. (Ann Arbor, USA) [23]2017Near-normothermic EVLP in five human arms from organ donors for 24 h with shown tissue viability
Krezdorn et al. (Boston, USA; Hannover, Germany) [24]2018Normothermic EVLP in 8 porcine forelimbs for up to 12 h with subsequent replantation, notably lower expression of hypoxia-related genes in EVLP cohort
  1. EVP ex vivo perfusion, EVLP ex vivo limb perfusion, IRI ischemia-reperfusion injury