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Table 3 Platelet function tests for patients with thrombocytopenia

From: Expert consensus on the diagnosis and treatment of thrombocytopenia in adult critical care patients in China

Experiment nameExperimental principleClinical significanceLimitations
ThrombelastographyBased on blood viscoelasticity, the device activates coagulation through needle rotation, thus simulating coagulation in vitro1. It comprehensively reflect the function of coagulation factors, platelets, and fibrinolysis system
2. Detect residual heparin and guide heparin dosage
3. The graph can be used to evaluate the efficacy of thromboxane A2 (TXA2 in) inhibitors and P2Y12 receptor inhibitors.
Long test time
Coagulation and platelet function analyzerBased on blood viscoelasticity, the device observes vertical needle vibration to simulate coagulation in vitroIt comprehensively reflect the function of coagulation factors and platelets and is particularly accurate for evaluating platelet function 
Whole-blood platelet aggregation rateChanges in platelet aggregation electrode impedance caused by different stimuli1. Posttrauma or postoperative platelet function evaluation, and platelet count measurement
2. Evaluation of the efficacy of antiplatelet drugs (TXA2 inhibitors, P2Y12 receptor inhibitors)
1. The result may be affected when platelet count < 27 × 109/L
2. Test must be performed within 10 min of sample collection
VerifyNow platelet function analysisCassette detection based on changes in light signals during platelet aggregation1. Posttrauma or postoperative platelet function evaluation to guide platelet transfusion
2. Evaluation of the efficacy of antiplatelet drugs (TXA2 inhibitors, P2Y12 receptor inhibitors, glycoproteins IIb/IIIa receptor inhibitors)
1. Not recommended for hereditary platelet dysfunction
2. No established data on the effect of thrombocytopenia on the result
Flow cytometryDetection of fluorescent-labeled antibody and cell size via light scattering1. To diagnose defects in platelet surface glycoproteins or platelet secretion
2. To detect platelet-associated antibodies
Expensive