Table 3 Platelet function tests for patients with thrombocytopenia

Thrombelastography

Based on blood viscoelasticity, the device activates coagulation through needle rotation, thus simulating coagulation in vitro

1. It comprehensively reflect the function of coagulation factors, platelets, and fibrinolysis system

2. Detect residual heparin and guide heparin dosage

3. The graph can be used to evaluate the efficacy of thromboxane A2 (TXA2 in) inhibitors and P2Y12 receptor inhibitors.

Long test time

Coagulation and platelet function analyzer

Based on blood viscoelasticity, the device observes vertical needle vibration to simulate coagulation in vitro

It comprehensively reflect the function of coagulation factors and platelets and is particularly accurate for evaluating platelet function

Whole-blood platelet aggregation rate

Changes in platelet aggregation electrode impedance caused by different stimuli

1. Posttrauma or postoperative platelet function evaluation, and platelet count measurement

2. Evaluation of the efficacy of antiplatelet drugs (TXA2 inhibitors, P2Y12 receptor inhibitors)

1. The result may be affected when platelet count < 27 × 10⁹/L

2. Test must be performed within 10 min of sample collection

VerifyNow platelet function analysis

Cassette detection based on changes in light signals during platelet aggregation

1. Posttrauma or postoperative platelet function evaluation to guide platelet transfusion

2. Evaluation of the efficacy of antiplatelet drugs (TXA2 inhibitors, P2Y12 receptor inhibitors, glycoproteins IIb/IIIa receptor inhibitors)

1. Not recommended for hereditary platelet dysfunction

2. No established data on the effect of thrombocytopenia on the result

Flow cytometry

Detection of fluorescent-labeled antibody and cell size via light scattering

1. To diagnose defects in platelet surface glycoproteins or platelet secretion

2. To detect platelet-associated antibodies

Expensive