Table 5 Comparison of clinico-laboratory variables between combined Adv (cAdv), Non-Adv, and only Adv identified pathogen (OAIP) groups
Variables | cAdv groupa (n = 30) | Non-Adv group (n = 184) | OAIP groupb (n = 37) | P value |
|---|---|---|---|---|
Age (year, M[Q1-Q3]) | 21.5 [20.0–22.0] | 21.6 [20.0–22.0] | 21.5 [20.0–22.0] | 0.672 |
Smoking [n(%)] | < 0.001 | |||
Never smoker | 21 (70.0) | 125 (67.9) | 24 (64.9) | |
Ex-smoker | 3 (10.0) | 49 (26.6) | 4 (10.8) | |
Current smoker | 6 (20.0) | 10 (5.4) | 9 (24.3) | |
Recent smoker (< 30 d) | 2 (6.7) | 0 (0) | 2 (5.4) | |
Symptom duration(Time from symptom onset to admission) (d, x ± s) | 3.6 ± 1.5 | 3.2 ± 2.3 | 3.6 ± 2.0 | 0.154 |
Symptom and sign [n(%)] | ||||
Fever | 30 (100.0) | 157 (85.4) | 36 (97.3) | 0.062 |
Cough | 29 (96.7) | 157 (85.4) | 36 (97.3) | 0.145 |
Myalgia | 14 (46.7) | 56 (30.4) | 17 (45.9) | 0.264 |
Dyspnea (> mMRC scale II) | 3 (10.0) | 11 (6.1) | 2 (5.4) | 0.510 |
Purulent sputum | 12 (40.0) | 58 (31.7) | 11 (29.7) | 0.126 |
Headache | 20 (66.7) | 96 (52.4) | 28 (75.7) | 0.089 |
Nasal congestion/rhinorrhea | 20 (66.7) | 103 (55.8) | 24 (64.9) | 0.423 |
WBC count (109/L, x ± s) | 7.54 ± 4.28 | 8.13 ± 4.05 | 4.50 ± 4.02 | 0.045 |
Leukopenia (< 4 × 109/L) [n(%)] | 6 (20.0) | 10 (5.4) | 15 (40.5) | < 0.001 |
Leukocytosis (> 10 × 109/L) [n(%)] | 5 (16.7) | 52 (28.0) | 3 (8.1) | < 0.001 |
Lymphocyte (%, x ± s) | 23.84 ± 8.74 | 18.62 ± 9.15 | 20.46 ± 7.72 | 0.049 |
Monocyte (%, x ± s) | 14.75 ± 1.69 | 11.02 ± 3.45 | 9.35 ± 3.75 | 0.002 |
Platelet count (109/L, x ± s) | 141.4 ± 45.7 | 184.6 ± 63.3 | 131.2 ± 59.7 | < 0.001 |
Thrombocytopenia (< 150 × 109/L) [n(%)] | 7 (23.3) | 17 (9.2) | 15 (40.5) | < 0.001 |
Duration of fever after admission (d, x ± s) | 2.9 ± 1.8 | 2.0 ± 1.3 | 3.5 ± 1.4 | 0.121 |
Duration of fever after symptom onset (d, x ± s) | 5.6 ± 2.2 | 3.8 ± 2.4 | 6.0 ± 2.2 | 0.015 |
Mean temperature at admission day (°C, x ± s) | 37.8 ± 0.3 | 37.3 ± 0.3 | 37.7 ± 0.4 | 0.223 |
Numbers of maximal temperature at admission [n(%)] | ||||
Over 40 °C | 4 (13.3) | 5 (2.7) | 6 (16.2) | 0.016 |
39–40 °C | 10 (33.3) | 8 (4.3) | 14 (37.8) | 0.024 |
Responsiveness to antipyretics at admission [n(%)] | < 0.001 | |||
Complete response | 16 (53.3) | 122 (66.3) | 14 (37.8) | |
Partial response | 12 (40.0) | 60 (32.6) | 13 (35.1) | |
No response | 2 (6.7) | 2 (1.1) | 10 (27.1) | |