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Table 2 Main target genes of the differentially expressed miRNAs in the 24-h group compared with 2-h group

From: Dynamic changes in peripheral blood-targeted miRNA expression profiles in patients with severe traumatic brain injury at high altitude

Change in miRNA expression

Name of miRNA

Predicted target genes

Upregulated

miR-203

4/all family, member 4; elongation factor RNA polymerase II, 2

miR-146a

Zinc finger protein 826; tumor necrosis factor receptor-associated factor 6 (TRAF6)

miR-149

AP2-associated protein kinase 1; PH domain and leucine-rich repeat protein phosphatase

miR-23b

Zinc finger protein 138; fucosyltransferase (alpha-fucosyltransferase (1,3) 9

miR-let-7f

High mobility group AT-hook 2; chromosome 14 open reading frame 28

miR-363

Protects cardiomyocytes against hypoxia-induced apoptosis through regulation of Notch signaling

miR-29a

ATPase family AAA domain-containing protein 2B; peptidase inhibitor 15

miR-122

Chloride channel 4; regulatory factor X-associated protein

Downregulated

miR-199a-3p

Cadherin EGF LAG seven pass G-type receptor 2; SH3 domain-containing GRB2-like endophilin B1

miR-let-7a

Angiogenesis in rheumatoid arthritis via HIF-1α activation

miR-214

NMDA receptor-regulated 2; κ-opioid receptor