From: Biomarkers for patients with trauma associated acute respiratory distress syndrome
Injury pathway | Biomarker | Pattern in ARDS | Clinical association | Statistic description | Reference |
---|---|---|---|---|---|
Endothelial injury | Ang-2 | elevated | Predicting ARDS mortality | AUC: 0.74 (95% CI, 0.62–0.84) OR: 4.0 (95% CI, 1.6–10.2) | [18] |
[19] | |||||
L-Selectin | decreased | Higher ARDS incidence | Serum Concentration in ARDS: 262.7 g/L (95% CI, 113.5–411.9 g/L) | [23] | |
Epithelial injury | sRAGE | elevated | Early onset of ARDS ARDS incidence | 1773 (949–3227) vs. 1226 (773–1944) Fold change: 3 | [26] |
[27] | |||||
SP-D | decreased | Higher mortality Worse oxygenation ARDS diagnosis | AUC: 0.69 (95% CI, 0.6, 0.76) | [29] | |
[29] | |||||
[30] | |||||
CC16 | elevated | Lung contusion volume ARDS mortality | r = 0.78, P < 0.0001 | [31] | |
[33] | |||||
Coagulation | Histones | elevated | ARDS incidence SOFA scores | Fold change: 6.72 r = 0.55, P < 0.01 | [40] |
[40] | |||||
Inflammation | mtDNA | elevated | SIRS mortality | AUC: 0.725 (95% CI 0.613–0.837). RR: 20.4 (95% CI, 1.3–318) | [43] |
[45] |