Radioprotective effects of cimetidine on rats irradiated by long-term, low-dose-rate neutrons and 60Co γ-rays

Table 2 Effect of cimetidine on peripheral blood WBC counts in n-γ LDR rats (×10⁹/L, x ± s, n = 10)

Group	3rd day before IR	8th day	17th day	26th day
Normal control group	10.9 ± 1.6	11.6 ± 1.2	10.7 ± 1.2	10.0 ± 2.6
Radiation model group	10.8 ± 2.2	7.7 ± 1.0⁽¹⁾	8.2 ± 2.3⁽¹⁾	6.3 ± 0.7⁽¹⁾
20 mg/(kg · d) cimetidine group	10.7 ± 1.5	11.3 ± 2.1⁽³⁾	8.6 ± 1.3⁽¹⁾	7.2 ± 1.2^(1)(2)(4)
80 mg/(kg · d) cimetidine group	10.6 ± 1.7	9.0 ± 1.6⁽¹⁾⁽²⁾	7.9 ± 1.1⁽¹⁾	7.2 ± 1.0^(1)(2)(4)
160 mg/(kg · d) cimetidine group	10.5 ± 1.5	9.0 ± 1.9⁽¹⁾	8.4 ± 1.2⁽¹⁾	5.8 ± 1.2⁽¹⁾

⁽¹⁾ P < 0.01 compared with the normal control group; ⁽²⁾ P < 0.05, ⁽³⁾ P < 0.01 compared with the radiation model group; ⁽⁴⁾ P < 0.05 compared with the 160 mg/(kg · d) cimetidine group. The 8th, 17th and 26th day were the days that the rats were exposed to n-γ LDR for 7, 16 and 25 days, respectively

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