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Table 2 Effect of cimetidine on peripheral blood WBC counts in n-γ LDR rats (×109/L, x ± s, n = 10)

From: Radioprotective effects of cimetidine on rats irradiated by long-term, low-dose-rate neutrons and 60Co γ-rays

Group 3rd day before IR 8th day 17th day 26th day
Normal control group 10.9 ± 1.6 11.6 ± 1.2 10.7 ± 1.2 10.0 ± 2.6
Radiation model group 10.8 ± 2.2 7.7 ± 1.0(1) 8.2 ± 2.3(1) 6.3 ± 0.7(1)
20 mg/(kg · d) cimetidine group 10.7 ± 1.5 11.3 ± 2.1(3) 8.6 ± 1.3(1) 7.2 ± 1.2(1)(2)(4)
80 mg/(kg · d) cimetidine group 10.6 ± 1.7 9.0 ± 1.6(1)(2) 7.9 ± 1.1(1) 7.2 ± 1.0(1)(2)(4)
160 mg/(kg · d) cimetidine group 10.5 ± 1.5 9.0 ± 1.9(1) 8.4 ± 1.2(1) 5.8 ± 1.2(1)
  1. (1) P < 0.01 compared with the normal control group; (2) P < 0.05, (3) P < 0.01 compared with the radiation model group; (4) P < 0.05 compared with the 160 mg/(kg · d) cimetidine group. The 8th, 17th and 26th day were the days that the rats were exposed to n-γ LDR for 7, 16 and 25 days, respectively