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Table 1 Roles of IL-33/ST2 in sepsis models

From: Role of the IL-33-ST2 axis in sepsis

Disease Role of IL-33/ST2 Referenced
Sepsis Sepsis patients have higher levels of serum IL-33 and sST2 [104108]
Endotoxemia ST2 negatively regulates TLR4 signaling and maintains LPS tolerance [109]
Endotoxemia ST2 negatively regulates TLR2 signaling, but is not required for BLP tolerance [110]
Endotoxemia IL-33 enhances LPS-induced proinflammatory mediators in mouse macrophages in a ST2-dependent manner [111, 113, 114]
Endotoxemia sST2 reduces LPS-mediated mortality and inhibits LPS-induced proinflammatory cytokines [115117]
Endotoxemia sST2 reduces inflammatory cell infiltration and vascular leakage, and suppresses proinflammatory cytokine production in lung tissues [120, 121]
Abdominal sepsis ST2 deletion protects mice challenged with secondary pneumonia [122]
Abdominal sepsis ST2 deficiency increases the susceptibility to sepsis [123]
Streptococcus pneumoniae infection ST2 deficiency protects mice challenged with S. pneumonia [124]
Abdominal sepsis IL-33 enhances neutrophil recruitment and protects mice with more efficient bacterial clearance and improved survival [125, 126]
Abdominal sepsis IL-33 administration attenuates organ damage in the late phase of sepsis [126]
Staphylococcus aureus infection IL-33 administration facilitates neutrophil recruitment and bacterial clearance [127]