Table 5 Growth factors for external using products approved for marketing by the SFDA

Zhuhai Essex Bio-Pharmaceutical

1998

Recombinant bovine basic fibroblast growth factor

Burn and scald wounds: including shallow II degree and deep II degree wounds, granulation wounds and inhalation injuries.

* Acute wounds: bruises, contusions, combined injuries and cuts.

* Surgical incisions: incisions of surgery, orthopedics, gynaecology (such as lateral episiotomy and cesarean incision), otolaryngology, urology and proctology.

* Chronic wounds: diabetic ulcers, vascular ulcers, radiochemotherapy ulcers, bedsores, fistulas, residual wounds and cervical erosions.

* Skin grafting: skin donor site, skin grafting site, skin flap handling.

* Other applications: after plastic surgery, skin resurfacing, dermabrasion, nevus removal and laser therapy wounds.

SFDA Approval No.S10980077

1999

Recombinant bovine basic fibroblast growth factor Eye Drops

* Various corneal defects and punctate keratopathy.

* Recurrent punctate keratopathy in the shallow layer.

* Mild or moderate dry eye.

* Corneal operation and poor corneal healing after operation.

* Geographic (or nutritional) herpes simplex keratitis.

* Ballous keratitis.

* Corneal abrasion, mild and moderate chemical burns.

SFDA Approval No.S19991022

2005

Recombinant bovine basic fibroblast growth factor Gel

Treatment of various keratopathy, ocular traumas and foreign body removal.

* Corneal transplantation and eye surface reconstruction.

* Dry eye: especially dry eye due to corneal injury.

* Cataract surgery (ECCE. Phaco etc.): restoration of endothelium and reduction of edema.

* Corneal refractive surgery: repair damaged corneas before surgery, repair damaged nerves after surgery and treat postoperative dry eye

SFDA Approval No.S20050100

Beijing SL Pharmaceutical

2002

Lyophilized Recombinant Human Basic Fibroblast Growth Factor (rh-bFGF)

Chronic Cutaneous Ulcer and Burn Wounds

SFDA Approval No.S20020025

Nanhai Longtime Pharmaceutical

2004

Recombinant Human Basic Fibroblast Growth Factor for External Use

Chronic Cutaneous Ulcer and Burn Wounds

SFDA Approval No.S20040052

Shanghai Wanxing Bio-Pharmaceutical

2006

Lyophilized Recombinant Human Acidic Fibroblast Growth Factor For External Use

Chronic Cutaneous Ulcer and Burn Wounds

SFDA Approval No.S20060102

Guilin pavay gene Pharmaceutical

2002

Recombinant Human Epidermal Growth Factor Hydro Gel

Chronic Cutaneous Ulcer and Burn Wounds

SFDA Approval No.S20020111

Wuhan HITECK biological pharmaceutical

2006

Mouse nerve growth factor for injection

Peripheral nerve injury and peripheral neuropathy; Brain and spinal cord injury; Acute cerebrovascular disease, cerebral atrophy, Parkinson’s and Alzheimer’s disease.

SFDA Approval No.S20060051