Fig. 4
From: An ongoing search for potential targets and therapies for lethal sepsis
Distinct HMGB1-inhibition mechanisms of several herbal components. a Direct binding and inhibition of HMGB1 activities. b, c, d Divergent HMGB1 inhibition mechanisms. Different herbal components can inhibit HMGB1 action or release through divergently distinct mechanisms including PKR inactivation (Panel b), autophagic degradation (Panel c), or endocytic HMGB1 uptake and degradation (Panel d)